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Association of choroidal IL-17-producing T lymphocytes and macrophages with geographic atrophy

Abstract : Purpose: To evaluate the presence of interleukin-17 (IL-17)-producing cells in patients with geographic atrophy (GA). Methods: In this short report, we analyzed IL-17, CD3 and IBA-1 expression by immunohistochemistry on paraffin-embedded sections from 13 donors with a known history of GA, confirmed by fundus appearance and histology, and 7 age-matched control donors. Results and conclusion: we show that IL-17+ cells are found near areas of retinal pigmented epithelium (RPE) atrophy in eyes of GA patients. IL-17+ cells mainly localized to CD3+ cells, which identifies T lymphocytes, as well as IBA-1+ cells, which identifies mononuclear phagocytes. Therefore IL-17 could be involved in the pathological mechanisms that contribute to degeneration observed in GA.
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Submitted on : Friday, March 31, 2017 - 5:01:54 PM
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Serge Camelo, Sophie Lavalette, Xavier Guillonneau, William Raoul, Florian Sennlaub. Association of choroidal IL-17-producing T lymphocytes and macrophages with geographic atrophy. Ophthalmologica, Karger, 2016, 236 (1), pp.53-58. ⟨10.1159/000446587⟩. ⟨inserm-01499605⟩

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