Skip to Main content Skip to Navigation
Journal articles

A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway

Abstract : Schizophrenia patients are waiting for a treatment free of detrimental effects. Psychotic disorders are devastating mental illnesses associated with dysfunctional brain networks. Ongoing brain network gamma frequency (30–80 Hz) oscillations, naturally implicated in integrative function, are excessively amplified during hallucinations, in at-risk mental states for psychosis and first-episode psychosis. So, gamma oscillations represent a bioelectrical marker for cerebral network disorders with prognostic and therapeutic potential. They accompany sensorimotor and cognitive deficits already present in prodromal schizophrenia. Abnormally amplified gamma oscillations are reproduced in the corticothalamic systems of healthy humans and rodents after a single systemic administration, at a psychotomimetic dose, of the glutamate N-methyl-D-aspartate receptor antagonist ketamine. These translational ketamine models of prodromal schizophrenia are thus promising to work out a preventive noninvasive treatment against first-episode psychosis and chronic schizophrenia. In the present essay, transcranial electric stimulation (TES) is considered an appropriate preventive therapeutic modality because it can influence cognitive performance and neural oscillations. Here, I highlight clinical and experimental findings showing that, together, the corticothalamic pathway, the thalamus, and the glutamatergic synaptic transmission form an etiopathophysiological backbone for schizophrenia and represent a potential therapeutic target for preventive TES of dysfunctional brain networks in at-risk mental state patients against psychotic disorders.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-01497784
Contributor : Christine Dupuis <>
Submitted on : Wednesday, March 29, 2017 - 11:45:34 AM
Last modification on : Friday, June 26, 2020 - 11:08:05 AM

File

brainsci-07-00034.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Didier Pinault. A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway. Behavioral and Brain Sciences, Cambridge University Press (CUP), 2017, 7, pp.34 - 34. ⟨10.3390/brainsci7040034⟩. ⟨inserm-01497784⟩

Share

Metrics

Record views

153

Files downloads

397