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Nuclear medicine for photodynamic therapy in cancer: planning, monitoring and nuclear PDT

Abstract : Photodynamic therapy (PDT) is a modality with promising results for the treatment of various cancers. PDT is increasingly included in the standard of care for different pathologies. This therapy relies on the effects of light delivered to photosensitized cells. At different stages of delivery, PDT requires imaging toplan, evaluate and monitor treatment. The contribution of molecular imaging in this context is important and continues to increase. In this article, we review the contribution of nuclear medicine imaging in oncology to PDT for planning and therapeutic monitoring purposes. Several solutions have been proposed to plan PDT from nuclear medicine imaging. For instance, photosensitizer biodistribution has been evaluated with aradiolabeled photosensitizer or with conventionalradiopharmaceuticals on positron emission tomography. The effects of PDT delivery have also been explored with specific SPECT or PET radiopharmaceuticals to evaluate the effects on cells (apoptosis, necrosis, proliferation, metabolism) or vascular damage. Finally, the synergy between photosensitizers and radiopharmaceuticals has been studied considering the Cerenkov effect to activate photosensitized cells.
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https://www.hal.inserm.fr/inserm-01492527
Contributor : Maximilien Vermandel <>
Submitted on : Monday, March 20, 2017 - 10:43:33 AM
Last modification on : Wednesday, October 21, 2020 - 3:40:50 AM
Long-term archiving on: : Wednesday, June 21, 2017 - 12:50:41 PM

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Dris Kharroubi Lakouas, Damien Huglo, Serge Mordon, Maximilien Vermandel. Nuclear medicine for photodynamic therapy in cancer: planning, monitoring and nuclear PDT. Photodiagnosis and Photodynamic Therapy, Elsevier, 2017, Epub ahead of print. ⟨10.1016/j.pdpdt.2017.03.002⟩. ⟨inserm-01492527⟩

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