Skip to Main content Skip to Navigation
Journal articles

Sleep disorders in neurology French consensus. Type 1 and type 2 Narcolepsy: Investigations and follow-up

Abstract : In the new international classification of sleep disorders (ICSD-3), narcolepsy is differentiated into two distinct pathologies: type 1 narcolepsy (NT1) and type 2 narcolepsy (NT2). NT1 is characterised by periods of an irrepressible need to sleep, cataplexy (a sudden loss of muscle tone triggered by emotion) and in some cases the presence of symptoms such as hypnagogic hallucinations, sleep paralysis and disturbed night-time sleep. Its physiopathology is based on the loss of hypocretin neurons in the hypothalamus, seemingly connected to an auto-immune process. By definition, cataplexy is absent and the hypocretin levels in the CSF are normal in NT2. Confirming the diagnosis requires polysomnography and multiple sleep latency tests. The choice of further investigations is based on the presence or absence of typical cataplexy. Further investigations include HLA typing, lumbar puncture to measure the hypocretin level in the CSF, or even brain imagery in the case of narcolepsy suspected to be secondary to an underlying pathology. In this consensus we propose recommendations for the work-up to be carried out during diagnosis and follow-up for patients suffering from narcolepsy.
Document type :
Journal articles
Complete list of metadatas

Cited literature [21 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01484943
Contributor : Yves Dauvilliers <>
Submitted on : Wednesday, March 8, 2017 - 9:19:03 AM
Last modification on : Friday, October 16, 2020 - 5:22:16 PM
Long-term archiving on: : Friday, June 9, 2017 - 12:32:56 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Christelle Monaca, Patrica Franco, Pierre Philip, Yves Dauvilliers. Sleep disorders in neurology French consensus. Type 1 and type 2 Narcolepsy: Investigations and follow-up. Revue Neurologique, Elsevier Masson, 2017, 173 (1-2), pp.25-31. ⟨10.1016/j.neurol.2016.09.016⟩. ⟨inserm-01484943⟩

Share

Metrics

Record views

261