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In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs.

Abstract : Anti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test. The IC50 values obtained were heterogeneous. One isolate exhibited high IC50 values for almost all drugs tested. Pentamidine, which is the first-line treatment in French Guiana, showed efficacy at very low doses (mean of 0.0038 μg/mL). The concordance of the in vitro pentamidine results with the patients' clinical outcomes was 94% (K = 0.82).
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https://www.hal.inserm.fr/inserm-01481512
Contributor : Inserm Cic1424 Centre d'Investigation Clinique Antilles Guyane <>
Submitted on : Thursday, March 2, 2017 - 4:39:53 PM
Last modification on : Wednesday, September 2, 2020 - 3:23:05 AM
Long-term archiving on: : Wednesday, May 31, 2017 - 2:55:49 PM

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Marine Ginouvès, Stéphane Simon, Mathieu Nacher, Magalie Demar, Bernard Carme, et al.. In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2017, [Epub ahead of print]. ⟨10.4269/ajtmh.16-0373⟩. ⟨inserm-01481512⟩

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