Real-Time Assessment of Health-Care Requirements During the Zika Virus Epidemic in Martinique.

Alessio Andronico 1 Frédérique Dorléans 2 Jean-Louis Fergé 3 Henrik Salje 1, 4 Frédéric Ghawché 5 Aissatou Signate 6 Elise Daudens-Vaysse 7 Laure Baudouin 5 Timothée Dub 8 Maite Aubry 9 Van-Mai Cao-Lormeau 10 Martine Ledrans 2 Harold Noel 11 Henri-Pierre Mallet 12 Arnaud Fontanet 13 André Cabié 3 Simon Cauchemez 1, *
* Auteur correspondant
1 Modélisation mathématique des maladies infectieuses
2 Cellule Inter Régionale d'Epidémiologie des Antilles - Guyane
3 Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique]
4 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative
5 Centre Hospitalier de Polynésie Française
6 ESS - Environnement, Santé, Sociétés
7 ARS Martinique - Agence régionale de santé (ARS) de Martinique
8 Epidémiologie des Maladies Emergentes
9 ILM - Institut Louis Malardé [Papeete]
10 Pôle de recherche et de veille sur les maladies infectieuses émergentes
11 ISCR - Institut des Sciences Chimiques de Rennes
12 Direction de la Santé de la Polynésie Française
13 Institut Pasteur [Paris]
Abstract : The spread of Zika virus in the Americas has been associated with a surge in Guillain-Barré syndrome (GBS) cases. Given the severity of GBS, territories affected by Zika virus need to plan health-care resources to manage GBS patients. To inform such planning in Martinique, we analyzed Zika virus surveillance and GBS data from Martinique in real time with a modeling framework that captured dynamics of the Zika virus epidemic, the risk of GBS in Zika virus–infected persons, and the clinical management of GBS cases. We compared our estimates with those from the 2013–2014 Zika virus epidemic in French Polynesia. We were able to predict just a few weeks into the epidemic that, due to lower transmission potential and lower probability of developing GBS following infection in Martinique, the total number of GBS cases in Martinique would be substantially lower than suggested by simple extrapolations from French Polynesia. We correctly predicted that 8 intensive-care beds and 7 ventilators would be sufficient to treat GBS cases. This study showcased the contribution of modeling to inform local health-care planning during an outbreak. Timely studies that estimate the proportion of infected persons that seek care are needed to improve the predictive power of such approaches.
Keywords : epidemic forecasts Guillain-Barré syndrome health-care planning Zika virus Abbreviations: GBS Guillain-Barré syndrome CI credible interval ICU intensive care unit ZIKV Zika virus
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Article dans une revue
American Journal of Epidemiology, Oxford University Press (OUP), 2017, [Epub ahead of print]. 〈10.1093/aje/kwx008〉
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Alessio Andronico, Frédérique Dorléans, Jean-Louis Fergé, Henrik Salje, Frédéric Ghawché, et al.. Real-Time Assessment of Health-Care Requirements During the Zika Virus Epidemic in Martinique.. American Journal of Epidemiology, Oxford University Press (OUP), 2017, [Epub ahead of print]. 〈10.1093/aje/kwx008〉. 〈inserm-01481405〉

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