U1048, Institute of Metabolic and Cardiovascular Diseases?I2MC, 1 avenue Jean Poulhès, B.P. 8422531432 Toulouse Cedex 4, France. 2 Université Toulouse III Paul-Sabatier, Biomedical Sciences Research Center 'Alexander Fleming', Fleming 34, 16672 Vari, Greece. 8 Service de Néphrologie?Médecine Interne?Hypertension Pédiatrique, p.31059, 10551. ,
10 Unité de recherche clinique pédiatrique, Module plurithémathique pédiatrique du Centre d'Investigation Clinique Toulouse 1436 Hôpital des enfants 330 avenue de grande bretagne, Diabète athérothrombose Thérapies Réunion Océan Indien, CYROI, 2, rue Maxime Rivière, 97490 Sainte Clotilde, p.31059, 31059. ,
Chronic kidney disease in children: the global perspective, Pediatric Nephrology, vol.17, issue.12, pp.1999-2009, 2007. ,
DOI : 10.1007/s00467-006-0410-1
Congenital Urinary Tract Obstruction: The Long View, Advances in Chronic Kidney Disease, vol.22, issue.4, pp.312-321, 2015. ,
DOI : 10.1053/j.ackd.2015.01.012
Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery, Journal of Clinical Investigation, vol.113, issue.7, pp.1051-1059, 2004. ,
DOI : 10.1172/JCI20049DS1
Congenital ureteropelvic junction obstruction: human disease and animal models, International Journal of Experimental Pathology, vol.14, issue.Suppl. 2, pp.168-92, 2011. ,
DOI : 10.1111/j.1365-2613.2010.00727.x
URL : https://hal.archives-ouvertes.fr/inserm-00550883
Prognostic factors and biomarkers of congenital obstructive nephropathy, Pediatric Nephrology, vol.330, issue.8, pp.1411-420, 2015. ,
DOI : 10.1007/s00441-015-2273-x
Creatinine as the gold standard for kidney injury biomarker studies?, Nephrology Dialysis Transplantation, vol.24, issue.11, pp.3263-3268, 2009. ,
DOI : 10.1093/ndt/gfp428
Conservative Treatment of Ureteropelvic Junction Obstruction in Children with Antenatal Diagnosis of Hydronephrosis: Lessons Learned after 16 Years of Follow-Up, European Urology, vol.49, issue.4, pp.734-742, 2006. ,
DOI : 10.1016/j.eururo.2006.01.046
Responses of proximal tubular cells to injury in congenital renal disease: fight or flight, Pediatric Nephrology, vol.100, issue.4, pp.537-578, 2014. ,
DOI : 10.1007/s00467-013-2590-9
Label-free Quantitative Urinary Proteomics Identifies the Arginase Pathway as a New Player in Congenital Obstructive Nephropathy, Molecular & Cellular Proteomics, vol.13, issue.12, pp.3421-3455, 2014. ,
DOI : 10.1074/mcp.M114.040121
The Fate of Nephrons in Congenital Obstructive Nephropathy: Adult Recovery is Limited by Nephron Number Despite Early Release of Obstruction, The Journal of Urology, vol.194, issue.5, pp.1463-72, 2015. ,
DOI : 10.1016/j.juro.2015.04.078
An overview of microRNAs, Advanced Drug Delivery Reviews, vol.87, pp.3-14, 2015. ,
DOI : 10.1016/j.addr.2015.05.001
MicroRNA history: Discovery, recent applications, and next frontiers, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol.717, issue.1-2, pp.1-8, 2011. ,
DOI : 10.1016/j.mrfmmm.2011.03.009
URL : http://repositorium.sdum.uminho.pt/bitstream/1822/18666/1/Almeida%20MI_Mutation%20Res%20Fund%20%26%20Molec%20Mech%20Mutag-pp%202011.pdf
Development of microRNA therapeutics is coming of age, EMBO Molecular Medicine, vol.6, issue.7, pp.851-64, 2014. ,
DOI : 10.15252/emmm.201100899
Non-coding RNAs in human disease, Nature Reviews Genetics, vol.39, issue.12, pp.861-74, 2011. ,
DOI : 10.1038/nrg3074
MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring, Nephrology Dialysis Transplantation, vol.29, issue.4, pp.755-63, 2014. ,
DOI : 10.1093/ndt/gft223
miRNAs in urine: a mirror image of kidney disease?, Expert Review of Molecular Diagnostics, vol.15, issue.3, pp.361-74, 2015. ,
DOI : 10.1586/14737159.2015.1009449
Identification of a microRNA signature in renal fibrosis: role of miR-21, AJP: Renal Physiology, vol.301, issue.4, pp.793-801, 2011. ,
DOI : 10.1152/ajprenal.00273.2011
MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways, Science Translational Medicine, vol.4, issue.121, pp.121-118, 2012. ,
DOI : 10.1126/scitranslmed.3003205
Increased Circulating miR-21 Levels Are Associated with Kidney Fibrosis, PLoS ONE, vol.25, issue.2, p.58014, 2013. ,
DOI : 10.1371/journal.pone.0058014.t002
URL : http://doi.org/10.1371/journal.pone.0058014
MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases, Biochimie, vol.95, issue.7, pp.1355-1364, 2013. ,
DOI : 10.1016/j.biochi.2013.03.010
Suppression of microRNA-29 Expression by TGF-??1 Promotes Collagen Expression and Renal Fibrosis, Journal of the American Society of Nephrology, vol.23, issue.2, pp.252-65, 2012. ,
DOI : 10.1681/ASN.2011010055
TGF-??/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29, Journal of the American Society of Nephrology, vol.22, issue.8, pp.1462-74, 2011. ,
DOI : 10.1681/ASN.2010121308
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148701
MicroRNAs, Cell, vol.116, issue.2, pp.281-97, 2004. ,
DOI : 10.1016/S0092-8674(04)00045-5
URL : https://hal.archives-ouvertes.fr/hal-00369966
The Long, the Short, and the Unstructured: A Unifying Model of miRNA Biogenesis, Molecular Cell, vol.60, issue.1, pp.4-6, 2015. ,
DOI : 10.1016/j.molcel.2015.09.014
Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT), Journal of Molecular Medicine, vol.137, issue.6, pp.739-787, 2013. ,
DOI : 10.1007/s00109-013-1000-x
miRBase: microRNA sequences, targets and gene nomenclature, Nucleic Acids Research, vol.34, issue.90001, pp.140-144, 2006. ,
DOI : 10.1093/nar/gkj112
URL : http://doi.org/10.1093/nar/gkj112
Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat, PLoS ONE, vol.22, issue.9, p.75557, 2013. ,
DOI : 10.1371/journal.pone.0075557.s004
MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice, Molecular Therapy, vol.22, issue.4, pp.842-53, 2014. ,
DOI : 10.1038/mt.2013.235
Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc, Biochemical and Biophysical Research Communications, vol.417, issue.1, pp.371-376, 2012. ,
DOI : 10.1016/j.bbrc.2011.11.119
MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2, PLoS ONE, vol.5, issue.4, p.10147, 2010. ,
DOI : 10.1371/journal.pone.0010147.s002
Gene Expression, Cancer Biotherapy & Radiopharmaceuticals, vol.28, issue.2, pp.131-138, 2013. ,
DOI : 10.1089/cbr.2012.1307
URL : https://hal.archives-ouvertes.fr/hal-01499736
Downregulation of Microrna-126 Contributes to Tumorigenesis of Squamous Tongue Cell Carcinoma via Targeting KRAS, Medical Science Monitor, vol.22, pp.522-531, 2016. ,
DOI : 10.12659/MSM.895306
Upregulated microRNA-16 as an oncogene in renal cell carcinoma, Molecular Medicine Reports, vol.12, issue.1, pp.1399-404, 2015. ,
DOI : 10.3892/mmr.2015.3496
Cytotoxic activity of sunitinib and everolimus in Caki-1 renal cancer cells is accompanied by modulations in the expression of apoptosis-related microRNA clusters and BCL2 family genes, Biomedicine & Pharmacotherapy, vol.70, pp.33-40, 2015. ,
DOI : 10.1016/j.biopha.2014.12.043
The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma, The Journal of Immunology, vol.190, issue.8, pp.3905-3920, 2013. ,
DOI : 10.4049/jimmunol.1200822
Decreased MicroRNA Is Involved in the Vascular Remodeling Abnormalities in Chronic Kidney Disease (CKD), PLoS ONE, vol.26, issue.5, p.64558, 2013. ,
DOI : 10.1371/journal.pone.0064558.t002
miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury, Cell Death and Disease, vol.5, issue.10, p.899, 2013. ,
DOI : 10.1124/mol.111.077149
URL : http://doi.org/10.1038/cddis.2013.427
Podocyte-Specific Loss of Functional MicroRNAs Leads to Rapid Glomerular and Tubular Injury, Journal of the American Society of Nephrology, vol.19, issue.11, pp.2069-75, 2008. ,
DOI : 10.1681/ASN.2008020162
MicroRNA expression profiling of kidney tissues in patients with congenital ureteropelvic junction obstruction, Int J Clin Exp Pathol, vol.9, issue.6, pp.6455-61, 2016. ,
The KUPKB: a novel Web application to access multiomics data on kidney disease, The FASEB Journal, vol.26, issue.5, pp.2145-53, 2012. ,
DOI : 10.1096/fj.11-194381
URL : https://hal.archives-ouvertes.fr/inserm-00726822
Gene expression in early and progression phases of autosomal dominant polycystic kidney disease, BMC Research Notes, vol.1, issue.1, p.131, 2008. ,
DOI : 10.1186/1756-0500-1-131
Parallel Analysis of mRNA and microRNA Microarray Profiles to Explore Functional Regulatory Patterns in Polycystic Kidney Disease: Using PKD/Mhm Rat Model, PLoS ONE, vol.438, issue.1, p.53780, 2013. ,
DOI : 10.1371/journal.pone.0053780.s009
Microarray Analysis of Glomerular Gene Expression in Murine Lupus Nephritis, Journal of Pharmacological Sciences, vol.106, issue.1, pp.56-67, 2008. ,
DOI : 10.1254/jphs.FP0071337
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway, The Journal of Experimental Medicine, vol.13, issue.10, pp.1963-76, 2011. ,
DOI : 10.1182/blood-2005-01-0355
Notch in the kidney: development and disease, The Journal of Pathology, vol.15, issue.2, pp.394-403, 2012. ,
DOI : 10.1002/path.2967
Translational study of the Notch pathway in hypertensive nephropathy, Nefrologia, vol.34, issue.3, pp.369-76, 2014. ,
Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury, The Journal of Pathology, vol.5, issue.3, pp.286-99, 2012. ,
DOI : 10.1002/path.4076
URL : https://hal.archives-ouvertes.fr/inserm-00771471
Notch3 and kidney injury: never two without three, The Journal of Pathology, vol.105, issue.3, pp.266-73, 2012. ,
DOI : 10.1002/path.4101
Kick it up a notch: Notch signaling and kidney fibrosis, Kidney International Supplements, vol.4, issue.1, pp.91-97, 2014. ,
DOI : 10.1038/kisup.2014.17
Mouse Neuron navigator 1, a novel microtubule-associated protein involved in neuronal migration, Molecular and Cellular Neuroscience, vol.28, issue.4, pp.599-612, 2005. ,
DOI : 10.1016/j.mcn.2004.09.016
Next-generation sequencing identifies TGF-??1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1822, issue.4, pp.589-99, 2012. ,
DOI : 10.1016/j.bbadis.2012.01.008
Human let-7a miRNA blocks protein production on actively translating polyribosomes, Nature Structural & Molecular Biology, vol.285, issue.12, pp.1108-1122, 2006. ,
DOI : 10.1038/nsmb1173
Short RNAs Repress Translation after Initiation in Mammalian Cells, Molecular Cell, vol.21, issue.4, pp.533-575, 2006. ,
DOI : 10.1016/j.molcel.2006.01.031
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells, Science, vol.309, issue.5740, pp.1573-1579, 2005. ,
DOI : 10.1126/science.1115079
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship, Nature Reviews Genetics, vol.20, issue.4, pp.271-82, 2012. ,
DOI : 10.1038/nrg3162
Posttranscriptional Upregulation by MicroRNAs, Wiley Interdisciplinary Reviews: RNA, vol.31, issue.3, pp.311-341, 2012. ,
DOI : 10.1002/wrna.121
AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2, Cell, vol.128, issue.6, pp.1105-1123, 2007. ,
DOI : 10.1016/j.cell.2007.01.038
Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation, Science, vol.318, issue.5858, pp.1931-1935, 2007. ,
DOI : 10.1126/science.1149460
MicroRNA-10a Binds the 5???UTR of Ribosomal Protein mRNAs and Enhances Their Translation, Molecular Cell, vol.30, issue.4, pp.460-71, 2008. ,
DOI : 10.1016/j.molcel.2008.05.001
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, Int J Genomics, vol.2014, p.970607, 2014. ,
Urinary miR-21, miR-29, and miR-93: Novel Biomarkers of Fibrosis, American Journal of Nephrology, vol.36, issue.5, pp.412-420, 2012. ,
DOI : 10.1159/000343452
miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy, Scientific Reports, vol.30, issue.1, p.27209, 2016. ,
DOI : 10.1016/S0167-9473(98)00096-6
URL : https://hal.archives-ouvertes.fr/hal-01339801
miR-21???Containing Microvesicles from Injured Tubular Epithelial Cells Promote Tubular Phenotype Transition by Targeting PTEN Protein, The American Journal of Pathology, vol.183, issue.4, pp.1183-96, 2013. ,
DOI : 10.1016/j.ajpath.2013.06.032
URL : http://doi.org/10.1016/j.ajpath.2013.06.032
Expression, Circulation, and Excretion Profile of MicroRNA-21, -155, and -18a Following Acute Kidney Injury, Toxicological Sciences, vol.129, issue.2, pp.256-67, 2012. ,
DOI : 10.1093/toxsci/kfs210
Urinary MicroRNA-10a and MicroRNA-30d Serve as Novel, Sensitive and Specific Biomarkers for Kidney Injury, PLoS ONE, vol.71, issue.12, p.51140, 2012. ,
DOI : 10.1371/journal.pone.0051140.s004
miR-192 Mediates TGF-??/Smad3-Driven Renal Fibrosis, Journal of the American Society of Nephrology, vol.21, issue.8, pp.1317-1342, 2010. ,
DOI : 10.1681/ASN.2010020134
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938591
Transforming Growth Factor-??-Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy, Diabetes, vol.62, issue.9, pp.3151-62, 2013. ,
DOI : 10.2337/db13-0305
TGF-beta induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy, Sci Signal, vol.6, issue.278, p.43, 2013. ,
miRNAs in Urine Extracellular Vesicles as Predictors of Early-Stage Diabetic Nephropathy, Journal of Diabetes Research, vol.28, issue.4, p.7932765, 2016. ,
DOI : 10.2337/db09-1736
Glomerulotubular disconnection in neonatal mice after relief of partial ureteral obstruction, Kidney International, vol.72, issue.9, pp.1103-1115, 2007. ,
DOI : 10.1038/sj.ki.5002512
Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy, The FASEB Journal, vol.23, issue.1, pp.134-176, 2009. ,
DOI : 10.1096/fj.08-115600
URL : https://hal.archives-ouvertes.fr/hal-00360882
Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes, Biological Chemistry, vol.387, issue.1, pp.15-22, 2006. ,
DOI : 10.1515/BC.2006.004
The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells, Oncotarget, vol.7, p.14125, 2016. ,
Gene ARMADA: an integrated multi-analysis platform for microarray data implemented in MATLAB, BMC Bioinformatics, vol.10, issue.1, p.354, 2009. ,
DOI : 10.1186/1471-2105-10-354