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Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans

Abstract : Background: Blood vitamin E concentrations are modulated by dietary, metabolic, and genetic factors. CD36 (cluster of differentiation 36), a class B scavenger receptor, might be involved in tissue vitamin E uptake and thus would influence blood vitamin E concentrations. Objective: The goal of the study was to assess the association between CD36 single nucleotide polymorphisms (SNPs) and plasma α-tocopherol concentrations in humans. Design: A subsample from the adult SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort (n = 621) and the adolescent cross-sectional HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study (n = 993) were genotyped for CD36 SNPs (4 and 10 SNPs, respectively). Fasting plasma α-tocopherol concentrations were assayed by using HPLC. Associations were determined by haplotype analyses and by general linear regression models. Results: In the SU.VI.MAX subsample, haplotype analyses showed that some haplotypes of SNPs rs1984112, rs1527479, rs7755, and rs1527483 tended to be associated with plasma α-tocopherol concentrations (P = 0.08 and P = 0.09 for haplotypes 1222 and 1122, respectively). We then investigated the whole known common genetic variability (10 SNPs) of CD36 in the HELENA Study. Three SNPs were associated with lower plasma α-tocopherol concentrations (rs1984112: −3.2%, P = 0.053; rs1761667: −2.9%, P = 0.046; rs1527479: −3.7%, P = 0.0061). After correction for multiple testing, the association between rs1527479 and α-tocopherol concentrations remained significant. This association was modulated by concentrations of fasting serum triglycerides (P for interaction = 0.006) and long-chain polyunsaturated fatty acids (P for interaction = 0.005). Conclusion: Our results suggest that CD36 can modulate blood α-tocopherol concentrations and may therefore be involved in the intestinal absorption or tissue uptake of vitamin E
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https://www.hal.inserm.fr/inserm-01478659
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Submitted on : Tuesday, February 28, 2017 - 11:47:33 AM
Last modification on : Monday, August 10, 2020 - 4:04:15 PM

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S. Lecompte, F. Szabo de Edelenyi, L. Goumidi, G. Maiani, G. Moschonis, et al.. Polymorphisms in the CD36/FAT gene are associated with plasma vitamin E concentrations in humans. American Journal of Clinical Nutrition, American Society for Nutrition, 2011, 93 (3), pp.644 - 651. ⟨10.3945/ajcn.110.004176⟩. ⟨inserm-01478659⟩

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