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Intestinal absorption of vitamin D: from the meal to the enterocyte

Abstract : Vitamin D plays key roles in bone, infectious, inflammatory and metabolic diseases. As most people get inadequate sun exposure for sufficient vitamin D status, they need adequate intake of dietary vitamin D. Many studies see optimizing vitamin D status as a public health priority. It is thus vital to gain deeper insight into vitamin D intestinal absorption. It was long assumed that vitamin D intestinal absorption is a passive process, but new data from our laboratory showed that it is actually far more complex than previously thought. This review describes the fate of vitamin D in the human upper gastrointestinal lumen during digestion and focuses on the proteins involved in the intestinal membrane and cellular transport of vitamin D across the enterocyte. Although recent data significantly improve our understanding of vitamin D intestinal absorption, further studies are still needed to increase our knowledge of the molecular mechanisms underlying this phenomenon
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https://www.hal.inserm.fr/inserm-01478584
Contributor : Emmanuelle Reboul <>
Submitted on : Tuesday, February 28, 2017 - 11:22:31 AM
Last modification on : Thursday, May 28, 2020 - 12:04:23 PM

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Emmanuelle Reboul. Intestinal absorption of vitamin D: from the meal to the enterocyte. Food and Function, Cambridge : Royal Society of Chemistry, 2015, 6 (2), pp.356 - 362. ⟨10.1039/c4fo00579a⟩. ⟨inserm-01478584⟩

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