M. Blachier, H. Leleu, M. Peck-radosavljevic, D. Valla, and F. Roudot-thoraval, The burden of liver disease in Europe: A review of available epidemiological data, Journal of Hepatology, vol.58, issue.3, pp.593-608, 2013.
DOI : 10.1016/j.jhep.2012.12.005

Y. Deugnier, B. Turlin, S. Harrison, and B. Bacon, Iron and hepatocellular carcinoma Relation of hemochromatosis with hepatocellular carcinoma: epidemiology, natural history, pathophysiology, screening, treatment, and prevention, J Gastroenterol Hepatol Med Clin North Am, vol.1689, pp.491-4391, 2001.

G. Brittenham and D. Badman, Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Workshop. Noninvasive measurement of iron: report of an NIDDK workshop, N Engl J Med Blood, vol.3131016, pp.1256-62, 1985.

S. Pierre, T. Clark, P. Chua-anusorn, W. Fleming, A. Jeffrey et al., Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance doi:10.1182/blood-2004-01-0177 MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients, Blood Blood, vol.1051068, pp.855-611460, 2005.

H. Chandarana, R. Lim, J. Jensen, C. Hajdu, M. Losada et al., -Weighted Sequence, American Journal of Roentgenology, vol.193, issue.5, pp.1261-1268, 1996.
DOI : 10.2214/AJR.08.1996

M. Garbowski, J. Carpenter, G. Smith, M. Roughton, M. Alam et al., Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan, Journal of Cardiovascular Magnetic Resonance, vol.16, issue.1, pp.40-50, 2014.
DOI : 10.1002/mrm.24607

B. Henninger, H. Zoller, S. Rauch, A. Finkenstedt, M. Schocke et al., R2* Relaxometry for the Quantification of Hepatic Iron Overload: Biopsy-Based Calibration and Comparison with the Literature, R??Fo - Fortschritte auf dem Gebiet der R??ntgenstrahlen und der bildgebenden Verfahren, vol.187, issue.06, pp.472-481, 2015.
DOI : 10.1055/s-0034-1399318

Y. Gandon, D. Olivié, D. Guyader, C. Aubé, F. Oberti et al., Non-invasive assessment of hepatic iron stores by MRI, The Lancet, vol.363, issue.9406, pp.357-62, 2004.
DOI : 10.1016/S0140-6736(04)15436-6

J. Alústiza, J. Artetxe, A. Castiella, C. Agirre, J. Emparanza et al., MR Quantification of Hepatic Iron Concentration, Radiology, vol.230, issue.2, pp.479-84, 2004.
DOI : 10.1148/radiol.2302020820

O. Ernst, C. Rose, G. Sergent, L. Herminé, and C. , Hepatic iron overload: quantification with MR imaging at 1.5 T., American Journal of Roentgenology, vol.172, issue.4, pp.1141-1143, 1999.
DOI : 10.2214/ajr.172.4.10587170

A. Castiella, J. Alústiza, J. Emparanza, E. Zapata, B. Costero et al., Liver iron concentration quantification by MRI: are recommended protocols accurate enough for clinical practice?, European Radiology, vol.26, issue.Suppl I, pp.137-178, 2011.
DOI : 10.1016/S1521-6926(02)90214-8

P. Brissot, M. Troadec, E. Bardou-jacquet, L. Lan, C. Jouanolle et al., Current approach to hemochromatosis, Blood Reviews, vol.22, issue.4, pp.195-210, 2008.
DOI : 10.1016/j.blre.2008.03.001

A. Meloni, V. Positano, P. Keilberg, D. Marchi, D. Pepe et al., Feasibility, reproducibility, and reliability for the T*2 iron evaluation at 3 T in comparison with 1.5 T, Magnetic Resonance in Medicine, vol.12, issue.suppl 1, pp.543-51, 2012.
DOI : 10.1186/1532-429X-12-S1-P275

P. Storey, A. Thompson, C. Carqueville, J. Wood, R. De-freitas et al., R2* imaging of transfusional iron burden at 3T and comparison with 1.5T, Journal of Magnetic Resonance Imaging, vol.29, issue.3, pp.540-547, 2007.
DOI : 10.1182/asheducation-2004.1.14

D. Rockey, S. Caldwell, Z. Goodman, R. Nelson, and A. Smith, Liver biopsy, Hepatology, vol.33, issue.Suppl 4, pp.1017-1061, 2009.
DOI : 10.1007/s00247-003-1044-0

B. Bacon, P. Adams, K. Kowdley, L. Powell, and A. Tavill, Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases, Hepatology, vol.23, issue.5 Suppl 1, pp.328-371, 2011.
DOI : 10.1155/2009/839308

T. Poynard, P. Bedossa, and P. Opolon, Natural history of liver fibrosis progression in patients with chronic hepatitis C, The Lancet, vol.349, issue.9055, pp.825-857, 1997.
DOI : 10.1016/S0140-6736(96)07642-8

M. Barry and S. Sherlock, MEASUREMENT OF LIVER-IRON CONCENTRATION IN NEEDLE-BIOPSY SPECIMENS, The Lancet, vol.297, issue.7690, pp.100-103, 1971.
DOI : 10.1016/S0140-6736(71)90838-5

C. Rose, P. Vandevenne, E. Bourgeois, N. Cambier, and O. Ernst, Liver iron content assessment by routine and simple magnetic resonance imaging procedure in highly transfused patients, European Journal of Haematology, vol.80, issue.2, pp.145-154, 2006.
DOI : 10.1002/jmri.10332

P. Dongiovanni, A. Fracanzani, S. Fargion, and L. Valenti, Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target, Journal of Hepatology, vol.55, issue.4, pp.920-952, 2011.
DOI : 10.1016/j.jhep.2011.05.008

L. Valenti, A. Fracanzani, E. Bugianesi, P. Dongiovanni, E. Galmozzi et al., HFE Genotype, Parenchymal Iron Accumulation, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease, Gastroenterology, vol.138, issue.3, pp.905-917, 2010.
DOI : 10.1053/j.gastro.2009.11.013
URL : https://iris.unito.it/bitstream/2318/85426/1/539419_postprintok.pdf

L. Valenti, A. Fracanzani, P. Dongiovanni, E. Bugianesi, G. Marchesini et al., Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study, Am J Gastroenterol, vol.102, 2007.

F. Equitani, J. Fernandez-real, G. Menichella, M. Koch, M. Calvani et al., Bloodletting Ameliorates Insulin Sensitivity and Secretion in Parallel to Reducing Liver Iron in Carriers of HFE Gene Mutations, Diabetes Care, vol.31, issue.1, pp.3-8, 2008.
DOI : 10.2337/dc07-0939

N. Ghugre, E. Doyle, P. Storey, and J. Wood, Relaxivity-iron calibration in hepatic iron overload: Predictions of a Monte Carlo model, Magnetic Resonance in Medicine, vol.81, issue.3, 2014.
DOI : 10.1016/j.ejrad.2010.12.069

M. Anwar, J. Wood, D. Manwani, B. Taragin, S. Oyeku et al., Hepatic Iron Quantification on 3 Tesla (3???T) Magnetic Resonance (MR): Technical Challenges and Solutions, Radiology Research and Practice, vol.307, issue.27, pp.628150-628160, 2013.
DOI : 10.1111/j.1365-2141.2004.05104.x
URL : http://doi.org/10.1155/2013/628150

N. Ghugre, T. Coates, M. Nelson, and J. Wood, Mechanisms of tissue-iron relaxivity: Nuclear magnetic resonance studies of human liver biopsy specimens, Magnetic Resonance in Medicine, vol.401, issue.5, pp.1185-93, 2005.
DOI : 10.1148/radiology.169.3.3186986

P. Peng, Z. Huang, L. Long, F. Zhao, C. Li et al., Liver iron quantification by 3 tesla MRI: Calibration on a rabbit model, Journal of Magnetic Resonance Imaging, vol.89, issue.6, pp.1585-90, 2013.
DOI : 10.1002/mrm.1910310605

J. Wood, C. Enriquez, N. Ghugre, J. Tyzka, S. Carson et al., MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients, Blood, vol.106, issue.4, pp.1460-1465, 2005.
DOI : 10.1182/blood-2004-10-3982
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895207

E. Outwater, R. Blasbalg, E. Siegelman, and M. Vala, Detection of lipid in abdominal tissues with opposed-phase gradient-echo images at 1.5 T: techniques and diagnostic importance., RadioGraphics, vol.18, issue.6, pp.1465-80, 1998.
DOI : 10.1148/radiographics.18.6.9821195

E. Siegelman, MR imaging of diffuse liver disease. Hepatic fat and iron, Magn Reson Imaging Clin N Am, vol.5, pp.347-65, 1997.

W. Dixon, Simple proton spectroscopic imaging., Radiology, vol.153, issue.1, pp.189-94, 1984.
DOI : 10.1148/radiology.153.1.6089263

M. Fishbein and W. Stevens, Rapid MRI using a modified Dixon technique: a non-invasive and effective method for detection and monitoring of fatty metamorphosis of the liver, Pediatric Radiology, vol.31, issue.11, pp.806-815, 2001.
DOI : 10.1007/s002470100547

G. Glover, Multipoint dixon technique for water and fat proton and susceptibility imaging, Journal of Magnetic Resonance Imaging, vol.94, issue.5, pp.521-551, 1991.
DOI : 10.1148/radiology.177.2.2217760