K. Yamagata, Mutations in the hepatocyte nuclear factor-1?? gene in maturity-onset diabetes of the young (MODY3), Nature, vol.384, issue.6608, pp.455-458, 1996.
DOI : 10.1038/384455a0

F. M. Ashcroft and P. Rorsman, Diabetes Mellitus and the ?? Cell: The Last Ten Years, Cell, vol.148, issue.6, pp.1160-1171010, 2012.
DOI : 10.1016/j.cell.2012.02.010

C. Bellanne-chantelot, Clinical characteristics and diagnostic criteria of maturity-onset diabetes of the young (MODY) due to molecular anomalies of the HNF1A gene. The Journal of clinical endocrinology and metabolism 96, pp.1346-1351, 2011.

S. H. Kim, Genetic Modifiers of the Age at Diagnosis of Diabetes (MODY3) in Carriers of Hepatocyte Nuclear Factor-1?? Mutations Map to Chromosomes 5p15, 9q22, and 14q24, Diabetes, vol.52, issue.8, pp.2182-2186, 2003.
DOI : 10.2337/diabetes.52.8.2182

C. Bellanne-chantelot, The Type and the Position of HNF1A Mutation Modulate Age at Diagnosis of Diabetes in Patients with Maturity-Onset Diabetes of the Young (MODY)-3, Diabetes, vol.57, issue.2, pp.503-508, 2008.
DOI : 10.2337/db07-0859

M. Pontoglio, Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice., Journal of Clinical Investigation, vol.101, issue.10, pp.2215-2222, 1998.
DOI : 10.1172/JCI2548
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508809

Y. H. Lee, B. Sauer, and F. J. Gonzalez, ?? Knockout Mouse, Molecular and Cellular Biology, vol.18, issue.5, pp.3059-3068, 1998.
DOI : 10.1128/MCB.18.5.3059

M. Pontoglio, HNF1?? controls renal glucose reabsorption in mouse and man, EMBO reports, vol.270, issue.4, pp.359-365, 2000.
DOI : 10.1093/embo-reports/kvd071
URL : https://hal.archives-ouvertes.fr/hal-00174799

I. D. Dukes, Defective Pancreatic ??-Cell Glycolytic Signaling in Hepatocyte Nuclear Factor-1??-deficient Mice, Journal of Biological Chemistry, vol.273, issue.38, pp.24457-24464, 1998.
DOI : 10.1074/jbc.273.38.24457

R. L. Pongratz, Mitochondrial Dysfunction Contributes to Impaired Insulin Secretion in INS-1 Cells with Dominant-negative Mutations of HNF-1?? and in HNF-1??-deficient Islets, Journal of Biological Chemistry, vol.284, issue.25, pp.16808-16821, 2009.
DOI : 10.1074/jbc.M807723200

D. Q. Shih, Loss of HNF-1?? Function in Mice Leads to Abnormal Expression of Genes Involved in Pancreatic Islet Development and Metabolism, Diabetes, vol.50, issue.11, pp.2472-2480, 2001.
DOI : 10.2337/diabetes.50.11.2472

S. F. Boj, M. Parrizas, M. A. Maestro, and J. Ferrer, A transcription factor regulatory circuit in differentiated pancreatic cells, Proceedings of the National Academy of Sciences, vol.98, issue.25, pp.14481-14486, 2001.
DOI : 10.1073/pnas.241349398

J. M. Servitja, Hnf1?? (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver, Molecular and Cellular Biology, vol.29, issue.11, pp.2945-295901389, 2009.
DOI : 10.1128/MCB.01389-08

M. Pontoglio, Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome, Cell, vol.84, issue.4, pp.575-585, 1996.
DOI : 10.1016/S0092-8674(00)81033-8
URL : http://doi.org/10.1016/s0092-8674(00)81033-8

K. W. Broman, H. Wu, S. Sen, and G. A. Churchill, R/qtl: QTL mapping in experimental crosses, Bioinformatics, vol.19, issue.7, pp.889-890, 2003.
DOI : 10.1093/bioinformatics/btg112
URL : http://bioinformatics.oxfordjournals.org/cgi/content/short/19/7/889

R. Smith, K. Sheppard, K. Dipetrillo, and G. Churchill, Quantitative Trait Locus Analysis Using J/qtl, Methods in molecular biology, vol.573, pp.175-188, 2009.
DOI : 10.1007/978-1-60761-247-6_10

F. Brial, C. R. Lussier, K. Belleville, P. Sarret, and F. Boudreau, Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1?? (MODY3)???Deficient Mice, Diabetes, vol.64, issue.9, pp.3314-3320, 2015.
DOI : 10.2337/db15-0124

J. Dupuis, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, Nature Genetics, vol.49, issue.2, pp.105-116520, 2010.
DOI : 10.1038/ng.520

R. A. Scott, Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways, Nature Genetics, vol.41, issue.9, pp.991-10052385, 2012.
DOI : 10.1086/519795

M. Parrizas, Hepatic Nuclear Factor 1-?? Directs Nucleosomal Hyperacetylation to Its Tissue-Specific Transcriptional Targets, Molecular and Cellular Biology, vol.21, issue.9, pp.3234-3243, 2001.
DOI : 10.1128/MCB.21.9.3234-3243.2001
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC86965

B. Thorens, M. T. Guillam, F. Beermann, R. Burcelin, and M. Jaquet, Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic ?? Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion, Journal of Biological Chemistry, vol.275, issue.31, pp.23751-23758, 2000.
DOI : 10.1074/jbc.M002908200

T. M. Keane, Mouse genomic variation and its effect on phenotypes and gene regulation, Nature, vol.5, issue.7364, pp.289-294, 2011.
DOI : 10.1038/nature10413
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276836

S. F. Boj, D. Petrov, and J. Ferrer, Epistasis of transcriptomes reveals synergism between transcriptional activators Hnf1alpha and Hnf4alpha, PLoS genetics, vol.6, 2010.

J. Jo, H. Kang, M. Y. Choi, and D. S. Koh, How Noise and Coupling Induce Bursting Action Potentials in Pancreatic ??-Cells, Biophysical Journal, vol.89, issue.3, pp.1534-1542053181, 2005.
DOI : 10.1529/biophysj.104.053181
URL : http://doi.org/10.1529/biophysj.104.053181

S. Bonner-weir, Beta-cell turnover: its assessment and implications, Diabetes, vol.50, issue.Supplement 1, pp.20-24, 2001.
DOI : 10.2337/diabetes.50.2007.S20