Brain alterations in pediatric PTSD Functional brain alterations during self-reference processing in adolescents with sexual abuse related posttraumatic stress disorder: A preliminary report
Résumé
Interpersonal childhood traumas are associated with more severe post-traumatic stress disorder at adulthood and have a critical impact on the development of the self. We proposed to explore the functional brain changes during a self-reference processing task in adolescents with sexual abuse related post-traumatic stress disorder (N = 10), compared to healthy adolescents (N = 10). While patients showed no behavioral disturbances in self-reference processing, they exhibited changes in activity and connectivity in regions involved in emotional regulation (amygdala and dorsal prefrontal cortex) and semantic memory (temporal and ventrolateral prefrontal regions). These preliminary results suggest that these alterations may have an effect on self-esteem which may contribute to a possible retention and impairment of symptoms in adulthood.
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