Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff

Pierre Savatier; Pierre Osteil; Patrick Tam

doi:10.1016/j.scr.2017.01.008

Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff

Pierre Savatier ^{1, *} Pierre Osteil ^{2, 3} Patrick Tam ^{2, 3}

* Auteur correspondant

1 SBRI - Institut cellule souche et cerveau / Stem Cell and Brain Research Institute

2 Embryology Unit [Westmead, Australia]

3 School of Medical Sciences [Sydney, Australia]

Abstract : The diverse cell states and in vitro conditions for the derivation and maintenance of the mammalian embryo-derived pluripotent stem cells raise the questions of whether there are multiple states of pluripotency of the stem cells of each species, and if there are innate species-specific variations in the pluripotency state. We will address these questions by taking a snapshot of our knowledge of the properties of the pluripotent stem cells, focusing on the maintenance of pluripotency and inter-conversion of the different types of pluripotent stem cells from rodents , lagomorphs and primates. We conceptualize pluripotent stem cells acquiring a series of cellular states represented as terraces on a slope of descending gradient of pluripotency. We propose that reprogramming pluripotent stem cells from a primed to a naive state is akin to moving upstream over a steep cliff to a higher terrace.

Keywords : Pluripotent stem cells Mouse Rat Rabbit Primate

Type de document :

Article dans une revue

Stem cell research, Elsevier, 2017, 19, pp.104 - 112. 〈10.1016/j.scr.2017.01.008〉

Domaine :

Sciences du Vivant [q-bio] / Biologie cellulaire

Sciences du Vivant [q-bio] / Biotechnologies

Liste complète des métadonnées

Littérature citée [116 références] Voir Masquer Télécharger

http://www.hal.inserm.fr/inserm-01451139
Contributeur : Pierre Savatier <>
Soumis le : mardi 31 janvier 2017 - 16:51:59
Dernière modification le : vendredi 9 février 2018 - 17:08:01
Document(s) archivé(s) le : lundi 1 mai 2017 - 16:05:33

1-s2.0-S1873506117300090-main....

Publication financée par une institution

Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff

Fichier

Identifiants

Collections

Citation

Exporter

Métriques

79

104

Contact

Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff

Fichier

Identifiants

Collections

Citation

Exporter

Partager

Métriques

79

104

Contact