Skip to Main content Skip to Navigation
Journal articles

Association between iron level, glucose impairment and increased DNA damage during pregnancy

Abstract : Elevated circulating ferritin has been reported to increase the risk of gestational diabetes mellitus (GDM). When high ferritin translates into high iron stores, iron excess is also a condition leading to free radical damage. We aimed to evaluate the relationship between oxidative stress (OS) induced by iron status and GDM risk in non iron-supplemented pregnant women. Methods: This was a pilot observational study conducted on 93 non-anemic pregnant women. Iron status was assessed at the first trimester of gestation. Blood sampling was done at 24–28 weeks' gestation for oral glucose tolerance test (OGTT), insulin and biological markers of oxidative damage tests. Results: A significant increase in DNA damage was found in patients who developed GDM. Women with elevated DNA damage had a six-fold increased risk of developing GDM (Exp (B) = 6.851, P = 0.038; 95% CI [1.108–42.375]). The serum ferritin levels at first trimester were significantly correlated to lipid per-oxidation (rho = 0.24, p = 0.012). The stratified analysis suggests that ferritin is a modifying factor for the correlation of oxidative stress (OS) and glucose intolerance. Conclusion: Moderate ferritin levels due to iron intake without iron-supplement, at early pregnancy is a modifying factor for the correlation of oxidative damage and glucose intolerance in pregnant women. Larger studies to evaluate the risk of food iron intake induced increased oxidative damage in offspring are warranted to propose nutrition advice regarding iron intake in women with a high risk of GDM.
Complete list of metadatas

Cited literature [45 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01445962
Contributor : Christine Dupuis <>
Submitted on : Wednesday, January 25, 2017 - 2:51:39 PM
Last modification on : Tuesday, July 28, 2020 - 3:02:02 AM
Long-term archiving on: : Wednesday, April 26, 2017 - 3:11:15 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Salam Zein, Samar Rachidi, Nadine Shami, Iman Sharara, Khawla Cheikh-Ali, et al.. Association between iron level, glucose impairment and increased DNA damage during pregnancy. Journal of Trace Elements in Medicine and Biology, Elsevier, 2017, [Epub ahead of print]. ⟨10.1016/j.jtemb.2016.11.006⟩. ⟨inserm-01445962⟩

Share

Metrics

Record views

417