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Animal extrapolation in preclinical studies: An analysis of the tragic case of TGN1412

Mael Lemoine 1, *
* Corresponding author
Abstract : According to the received view, the transportation view, animal extrapolation consists in inductive prediction of the outcome of a mechanism in a target, based on an analogical mechanism in a model. Through an analysis of the failure of preclinical studies of TGN1412, an innovative drug, to predict the tragic consequences of its first-in-man trial in 2006, the received view is challenged by a proposed view of animal extrapolation, the chimera view. According to this view, animal extrapolation is based on a hypothesis about how human organisms work, supported by the amalgamation of results drawn from various experimental organisms, and only predicting the 'predictive grid', that is, a global framework of the effects to be expected.
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Submitted on : Saturday, January 14, 2017 - 6:44:00 PM
Last modification on : Thursday, March 12, 2020 - 3:02:14 PM
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Mael Lemoine. Animal extrapolation in preclinical studies: An analysis of the tragic case of TGN1412. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, Elsevier, 2017, 61, pp.35-45. ⟨10.1016/j.shpsc.2016.12.004⟩. ⟨inserm-01435609⟩

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