T. France and . Fondation-pour-la-recherche-médicale, European Genomic Institute for Diabetes " (EGID, ANR-10-LABX-46) and European Commission are acknowledged. B. Staels is a member of the

P. Libby, M. Aikawa, and U. Schonbeck, Cholesterol and atherosclerosis, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1529, issue.1-3, pp.299-309, 2000.
DOI : 10.1016/S1388-1981(00)00161-X

M. Phillips, Molecular Mechanisms of Cellular Cholesterol Efflux, Journal of Biological Chemistry, vol.289, issue.35, pp.24020-24029, 2014.
DOI : 10.1074/jbc.R114.583658

G. Chinetti-gbaguidi, C. S. Staels, and B. , Macrophage subsets in atherosclerosis, Nature Reviews Cardiology, vol.98, issue.1, pp.10-17, 2015.
DOI : 10.1155/2012/693083

S. Gordon and P. Taylor, Monocyte and macrophage heterogeneity, Nature Reviews Immunology, vol.33, issue.12, pp.953-964, 2005.
DOI : 10.1038/nri1733

H. Vosper, L. Patel, and T. Graham, The Peroxisome Proliferator-activated Receptor ?? Promotes Lipid Accumulation in Human Macrophages, Journal of Biological Chemistry, vol.276, issue.47, pp.44258-44265, 2001.
DOI : 10.1074/jbc.M108482200

T. Adhikary, A. Wortmann, and T. Schumann, The transcriptional PPAR??/?? network in human macrophages defines a unique agonist-induced activation state, Nucleic Acids Research, vol.43, issue.10, pp.5033-5051, 2015.
DOI : 10.1093/nar/gkv331

P. Thulin, T. Wei, and O. Werngren, MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor delta in human monocytes during the inflammatory response

M. Bouhlel, J. Brozek, and B. Derudas, Unlike PPAR??, PPAR?? or PPAR??/?? activation does not promote human monocyte differentiation toward alternative macrophages, Biochemical and Biophysical Research Communications, vol.386, issue.3, pp.459-462, 2009.
DOI : 10.1016/j.bbrc.2009.06.047

K. Kang, S. Reilly, and V. Karabacak, Adipocyte-Derived Th2 Cytokines and Myeloid PPAR?? Regulate Macrophage Polarization and Insulin Sensitivity, Cell Metabolism, vol.7, issue.6, pp.485-495, 2008.
DOI : 10.1016/j.cmet.2008.04.002
URL : http://doi.org/10.1016/j.cmet.2008.04.002

C. Rolling, D. Treton, and S. Pellegrini, IL4 and IL13 receptors share the ??c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells, FEBS Letters, vol.271, issue.1, pp.53-56, 1996.
DOI : 10.1016/0014-5793(96)00835-6

A. Li, C. Binder, and A. Gutierrez, Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPAR??, ??/??, and ??, Journal of Clinical Investigation, vol.114, issue.11, pp.1564-1576, 2004.
DOI : 10.1172/JCI18730

D. Mou, H. Yang, and C. Qu, Pharmacological Activation of Peroxisome Proliferator-Activated Receptor {Delta} Increases Sphingomyelin Synthase Activity in THP-1 Macrophage-Derived Foam Cell, Inflammation, vol.10, issue.2, pp.1538-1546, 2016.
DOI : 10.1186/1476-511X-10-46

L. Bojic, C. Sawyez, and D. Telford, Activation of Peroxisome Proliferator-Activated Receptor ?? Inhibits Human Macrophage Foam Cell Formation and the Inflammatory Response Induced by Very Low-Density Lipoprotein, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.32, issue.12, pp.2919-2928, 2012.
DOI : 10.1161/ATVBAHA.112.255208

A. Chawla, C. Lee, and Y. Barak, PPAR?? is a very low-density lipoprotein sensor in macrophages, Proceedings of the National Academy of Sciences, vol.100, issue.3, pp.1268-1273, 2003.
DOI : 10.1073/pnas.0337331100

C. Lee, K. Kang, and I. Mehl, Peroxisome proliferator-activated receptor ?? promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage, Proceedings of the National Academy of Sciences, vol.103, issue.7, pp.2434-2439, 2006.
DOI : 10.1073/pnas.0510815103

W. Oliver, J. Shenk, and M. Snaith, A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport, Proc Natl Acad Sci, pp.5306-5311, 2001.
DOI : 10.1073/pnas.091021198
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC33205

M. Ogata, M. Tsujita, and M. Hossain, On the mechanism for PPAR agonists to enhance ABCA1 gene expression, Atherosclerosis, vol.205, issue.2, pp.413-419, 2009.
DOI : 10.1016/j.atherosclerosis.2009.01.008

K. Chehaibi, L. Cedo, and J. Metso, PPAR-??/?? activation promotes phospholipid transfer protein expression, Biochemical Pharmacology, vol.94, issue.2, pp.101-108, 2015.
DOI : 10.1016/j.bcp.2015.01.016

J. Oram, G. Wolfbauer, and A. Vaughan, Phospholipid Transfer Protein Interacts with and Stabilizes ATP-binding Cassette Transporter A1 and Enhances Cholesterol Efflux from Cells, Journal of Biological Chemistry, vol.278, issue.52
DOI : 10.1074/jbc.M310695200

C. Lee, A. Chawla, and N. Urbiztondo, Transcriptional Repression of Atherogenic Inflammation: Modulation by PPAR??, Science, vol.302, issue.5644, pp.453-457, 2003.
DOI : 10.1126/science.1087344

J. Welch, M. Ricote, and T. Akiyama, PPAR?? and PPAR?? negatively regulate specific subsets of lipopolysaccharide and IFN-?? target genes in macrophages, Proceedings of the National Academy of Sciences, vol.100, issue.11, pp.6712-6717, 2003.
DOI : 10.1073/pnas.1031789100

G. Barish, A. Atkins, and M. Downes, PPAR?? regulates multiple proinflammatory pathways to suppress atherosclerosis, Proceedings of the National Academy of Sciences, vol.105, issue.11, pp.4271-4276, 2008.
DOI : 10.1073/pnas.0711875105
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393796

J. Odegaard, R. -. Gonzalez, R. , R. Eagle, and A. , Alternative M2 Activation of Kupffer Cells by PPAR?? Ameliorates Obesity-Induced Insulin Resistance, Cell Metabolism, vol.7, issue.6, pp.496-507, 2008.
DOI : 10.1016/j.cmet.2008.04.003

I. Tabas, Macrophage death and defective inflammation resolution in atherosclerosis, Nature Reviews Immunology, vol.811, issue.2, pp.36-46, 2010.
DOI : 10.1038/nri2675

L. Mukundan, J. Odegaard, and C. Morel, PPAR-?? senses and orchestrates clearance of apoptotic cells to promote tolerance, Nature Medicine, vol.200, issue.11, pp.1266-1272, 2009.
DOI : 10.1038/nm.2048

M. Sznaidman, C. Haffner, and P. Maloney, Novel selective small molecule agonists for peroxisome proliferator-activated receptor ?? (PPAR??)???synthesis and biological activity, Bioorganic & Medicinal Chemistry Letters, vol.13, issue.9, pp.1517-1521, 2003.
DOI : 10.1016/S0960-894X(03)00207-5

L. Bojic, A. Burke, and S. Chhoker, Peroxisome Proliferator-Activated Receptor ?? Agonist GW1516 Attenuates Diet-Induced Aortic Inflammation, Insulin Resistance, and Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.34, issue.1, pp.52-60, 2014.
DOI : 10.1161/ATVBAHA.113.301830

T. Graham, C. Mookherjee, and K. Suckling, The PPAR?? agonist GW0742X reduces atherosclerosis in LDLR???/??? mice, Atherosclerosis, vol.181, issue.1, pp.29-37, 2005.
DOI : 10.1016/j.atherosclerosis.2004.12.028

Y. Takata, J. Liu, and F. Yin, PPAR??-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis, Proceedings of the National Academy of Sciences, vol.105, issue.11, pp.4277-4282, 2008.
DOI : 10.1073/pnas.0708647105
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393800

N. Naya, K. Fukao, and A. Nakamura, A selective peroxisome proliferator-activated receptor ?? agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice, Metabolism, vol.65, issue.1, pp.16-25, 2016.
DOI : 10.1016/j.metabol.2015.09.016

J. Chin, J. Hong, and J. Lee, Selective peroxisome proliferator-activated receptor ?? isosteric selenium agonists as potent anti-atherogenic agents in vivo, Bioorganic & Medicinal Chemistry Letters, vol.20, issue.24, pp.7239-7242, 2010.
DOI : 10.1016/j.bmcl.2010.10.103

L. Piqueras, M. Sanz, and M. Perretti, Activation of PPAR??/?? inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release, Journal of Leukocyte Biology, vol.86, issue.1, pp.115-122, 2009.
DOI : 10.1189/jlb.0508284

G. Li, C. Chen, and S. Laing, Hematopoietic knockdown of PPAR?? reduces atherosclerosis in LDLR???/??? mice, Gene Therapy, vol.294, issue.1, pp.78-85, 2016.
DOI : 10.1038/gt.2015.78