Skip to Main content Skip to Navigation
Journal articles

Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides

Abstract : In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties of Opuntia ficus-indica cactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS exposure. Using four different structurally and biologically well-characterized LPS serotypes, we revealed a structure-related differential effect of LPS on fatty acid β-oxidation and antioxidant enzymes in peroxisomes: Escherichia coli-LPS decreased ACOX1 activity while Salmonella minnesota-LPS reduced only catalase activity. Different cactus cladode extracts showed an antioxidant effect through microglial catalase activity activation and an anti-inflammatory effect by reducing nitric oxide (NO) LPS-dependent production. These results suggest that cactus extracts may possess a neuroprotective activity through the induction of peroxisomal antioxidant activity and the inhibition of NO production by activated microglial cells.
Document type :
Journal articles
Complete list of metadatas

Cited literature [46 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01432713
Contributor : Stéphane Mandard <>
Submitted on : Thursday, January 12, 2017 - 6:54:10 AM
Last modification on : Friday, October 18, 2019 - 11:06:05 AM
Long-term archiving on: : Friday, April 14, 2017 - 1:27:08 PM

File

Molecules PDF DEFINITIF.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Fatima-Ezzahra Saih, Pierre Andreoletti, Stéphane Mandard, Norbert Latruffe, M'Hammed Saïd El Kebbaj, et al.. Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides. Molecules, MDPI, 2017, 22 (1), pp.E102. ⟨10.3390/molecules22010102⟩. ⟨inserm-01432713⟩

Share

Metrics

Record views

359

Files downloads

568