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Fasting circulating glicentin increases after bariatric surgery : glicentin in bariatric surgery

Abstract : Introduction: Bariatric surgery including the Roux-en-Y Gastric Bypass (RYGB) and the laparoscopic sleeve gastrectomy (LSG) is a well-established therapeutic option for patients with morbid or severe obesity. Metabolic modifications observed after bariatric surgery are thought to be, at least partly, linked to hormonal changes. While variation of several pro-glucagon-derived peptides during bariatric surgery is well documented, little is known about glicentin. The aim of this study was to investigate circulating glicentin variations after bariatric surgery. Material and methods: Thirty patients eligible for bariatric surgery (18 RYGB and 12 LSG procedures) were prospectively included in the University Hospital of Nice. Clinical data and fasting biological parameters were recorded pre-operatively, at 3, 6 and 12 months after bariatric surgery. Results: after bariatric surgery from 6 months and was more marked at 12 months (14 +/- 3.6 pmol/L at baseline vs 19.7 +/- 2.7 pmol/L at 12 months for RYGB, and 12.5 +/- 1.4 pmol/L vs 16.4 +/- 1.8 pmol/L for LSG, respectively). Compared to pre-operative values, the fold increase of glicentin at 12 months was 2 +/- 0.2 in the RYGB group and 1.6 +/- 0.3 in the LSG group. Glicentin variation after surgery did not correlate with anthropometric, glycemic or lipid parameter modifications. Conclusion: Fasting glicentin level increases after bariatric surgery suggesting the potential interest of this peptide as player and/or marker of physiological changes after bariatric surgery.
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Submitted on : Wednesday, January 11, 2017 - 3:06:04 PM
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Juliette Raffort, Patricia Panaïa-Ferrari, Fabien Lareyre, Pascal Bayer, Pascal Staccini, et al.. Fasting circulating glicentin increases after bariatric surgery : glicentin in bariatric surgery. Obesity Surgery, Springer Verlag, 2016, Epub ahead of print. ⟨10.1007/s11695-016-2493-5⟩. ⟨inserm-01432099⟩



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