Skip to Main content Skip to Navigation
Journal articles

Mechanisms of retinoic acid signaling during cardiogenesis

Abstract : Substantial experimental and epidemiological data have highlighted the interplay between nutritional and genetic factors in the development of congenital heart defects. Retinoic acid (RA), a derivative of vitamin A, plays a key role during vertebrate development including the formation of the heart. Retinoids bind to RA and retinoid X receptors (RARs and RXRs) which then regulate tissue-specific genes. Here, we will focus on the roles of RA signaling and receptors in gene regulation during cardiogenesis, and the consequence of deregulated retinoid signaling on heart formation and congenital heart defects.
Document type :
Journal articles
Complete list of metadata

Cited literature [197 references]  Display  Hide  Download
Contributor : Sonia Stefanovic Connect in order to contact the contributor
Submitted on : Thursday, March 29, 2018 - 10:34:12 AM
Last modification on : Wednesday, November 3, 2021 - 6:45:18 AM
Long-term archiving on: : Thursday, September 13, 2018 - 1:09:29 PM


Files produced by the author(s)




Sonia Stefanovic, Stéphane Zaffran. Mechanisms of retinoic acid signaling during cardiogenesis. Mechanisms of Development, Elsevier, 2017, 143, pp.9 - 19. ⟨10.1016/j.mod.2016.12.002⟩. ⟨inserm-01430833⟩



Record views


Files downloads