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Mechanisms of retinoic acid signaling during cardiogenesis

Abstract : Substantial experimental and epidemiological data have highlighted the interplay between nutritional and genetic factors in the development of congenital heart defects. Retinoic acid (RA), a derivative of vitamin A, plays a key role during vertebrate development including the formation of the heart. Retinoids bind to RA and retinoid X receptors (RARs and RXRs) which then regulate tissue-specific genes. Here, we will focus on the roles of RA signaling and receptors in gene regulation during cardiogenesis, and the consequence of deregulated retinoid signaling on heart formation and congenital heart defects.
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https://www.hal.inserm.fr/inserm-01430833
Contributor : Sonia Stefanovic <>
Submitted on : Thursday, March 29, 2018 - 10:34:12 AM
Last modification on : Wednesday, August 19, 2020 - 12:08:15 PM
Long-term archiving on: : Thursday, September 13, 2018 - 1:09:29 PM

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Sonia Stefanovic, Stéphane Zaffran. Mechanisms of retinoic acid signaling during cardiogenesis. Mechanisms of Development, Elsevier, 2017, 143, pp.9 - 19. ⟨10.1016/j.mod.2016.12.002⟩. ⟨inserm-01430833⟩

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