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Journal articles
Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B Supplementary data
Abstract : Activin B, which is strongly induced by inflammatory stimuli in the mouse liver, has recently appeared as a potent inductor of hepcidin in vitro, via the crossactivation of non-canonical SMAD1/5/8 signaling1,2. To confirm the cause and effect relationship between activin B, Smad1/5/8 phosphorylation, and hepcidin in vivo, we challenged Inhbb-/- mice (deficient in activin B) with LPS or infected them with a E. coli septicemic strain. Our data show that full induction of hepcidin expression by inflammatory stimuli requires a functional BMP6-activated signaling pathway in the hepatocyte but is independent of activin B and its activation of Smad1/5/8 signaling that likely occurs in other cells of the liver.
https://www.hal.inserm.fr/inserm-01430303
Contributor : Marie-Paule Roth <>
Submitted on : Monday, January 9, 2017 - 4:40:39 PM
Last modification on : Tuesday, May 26, 2020 - 8:45:54 PM
Long-term archiving on: : Monday, April 10, 2017 - 4:15:36 PM
Contributor : Marie-Paule Roth <>
Submitted on : Monday, January 9, 2017 - 4:40:39 PM
Last modification on : Tuesday, May 26, 2020 - 8:45:54 PM
Long-term archiving on: : Monday, April 10, 2017 - 4:15:36 PM
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letter actB KO.pdf
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