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How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?

Abstract : Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-3-phosphate dehydrogenase activate survival pathways (Akt and so on); phosphofructokinase 1 and triose phosphate isomerase participate in cell cycle activation; aldolase promotes epithelial mesenchymal transition; PKM2 enhances various nuclear effects such as transcription, stabilisation and so on. This review outlines the multiple non-glycolytic roles of glycolytic enzymes, which are essential for promoting cancer cells' survival, proliferation, chemoresistance and dissemination.
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Submitted on : Thursday, January 5, 2017 - 1:04:13 PM
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Hubert Lincet, Philippe Icard. How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?. Oncogene, Nature Publishing Group, 2014, 34 (29), pp.3751 - 3759. ⟨10.1038/onc.2014.320⟩. ⟨inserm-01427176⟩



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