Dengue infection in sickle cell patients in French Guiana

Abstract : Reports on dengue morbidity in patients with sickle cell disease (SCD) are scarce. Dengue is arthropod-borne viroses due to dengue virus (DENV) and affects populations with a high prevalence of SCD; therefore, the risk of morbidity may be increased. To determine the impact of dengue infection in SCD patients, we reviewed medical records during a vast outbreak of dengue virus serotype-2 (DENV-2) in French Guiana in 2012-2013. We identified 10 cases of laboratory-confirmed dengue infection; these were classified into A, B and C categories based on levels of severity of dengue according to World Health Organisation (WHO). The average age of SCD patients was 18.2 years. 1, 6 and 3 cases were classified as A, B and C WHO severity criteria, respectively. All patients had an important decrease in haematocrit (while one of the WHO severity criteria is the increase of haematocrit). Only one patient had decreased platelet count. Seven cases had vaso-occlusive crisis (VOC), six patients developed acute hepatitis and eight had a simultaneous bacterial infection. Six of them needed a blood transfusion. The results suggested that the WHO severity laboratory criteria of hemoconcentration and platelet counts were not helpful in the management of SCD patients. The morbidity was mainly caused by specific complications of SCD, especially VOC, likely facilitated by vascular endothelial damages consecutive to dengue fever, severe haemolysis, hepatitis and bacterial co-infections.
Type de document :
Article dans une revue
Journal of Virology and Retrovirology, 2015, 2 (1), pp.1-5
Liste complète des métadonnées

Littérature citée [15 références]  Voir  Masquer  Télécharger
Contributeur : Inserm Cic1424 Centre d'Investigation Clinique Antilles Guyane <>
Soumis le : lundi 19 décembre 2016 - 14:51:48
Dernière modification le : mercredi 18 juillet 2018 - 20:11:28
Document(s) archivé(s) le : lundi 20 mars 2017 - 21:20:57


2015, Mosnier - Dengue infecti...
Fichiers éditeurs autorisés sur une archive ouverte


  • HAL Id : inserm-01419456, version 1



Emilie Mosnier, Magalie Demar, Emmanuelle Bernit, Dominique Rousset, Loïc Epelboin, et al.. Dengue infection in sickle cell patients in French Guiana . Journal of Virology and Retrovirology, 2015, 2 (1), pp.1-5. 〈inserm-01419456〉



Consultations de la notice


Téléchargements de fichiers