RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor

Abstract : Highlights d Identification of SNPs near RhoB is associated with poor Vg9Vd2 T cell activation d RhoB activity and distribution in tumor cells modulate Vg9Vd2 T cell activation d Relocalization of RhoB induces membrane immobility of BTN3A1 d Tumor recognition by a Vg9Vd2 TCR depends on BTN3A1 conformation In Brief Sebestyen et al. show that Vg9Vd2TCR activation is modulated by the GTPase activity of RhoB in tumor cells, and by the relocalization of RhoB to BTN3A1. Subsequently, a phosphoantigen-induced conformational change in BTN3A1 leads to its recognition by Vg9Vd2TCRs.