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Journal articles
RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor
Zsolt Sebestyen
1
Wouter Scheper
1
Anna Vyborova
1
Siyi Gu
2
Zuzana Rychnavska
1
Marleen Schiffler
1
Astrid Cleven
1
Coraline Chéneau
1
Martje van Noorden
1
Cassie-Marie Peigné
3
Daniel Olive
4
Robert Jan Lebbink
5
Rimke Oostvogels
2
Tuna Mutis
2
Gerrit Jan Schuurhuis
6
Erin Adams
7
Emmanuel Scotet
3
Jürgen Kuball
1, *
*
Corresponding author
Zuzana Rychnavska 1
Author
Marleen Schiffler 1
Author
Astrid Cleven 1
Author
Coraline Chéneau 1
Author
Martje van Noorden 1
Author
Cassie-Marie Peigné 3
Author
Daniel Olive 4
Author
Robert Jan Lebbink 5
Author
Emmanuel Scotet 3
Author IdHAL : emmanuel-scotet ORCID : https://orcid.org/0000-0001-8010-9556
Jürgen Kuball 1
Correspondent author
1
Department of Hematology [Utrecht, the Netherlands] (Heidelberglaan 100 - 3584 CX Utrecht - Netherlands)
- Laboratory of Translational Immunology [Utrecht, the Netherlands] (Heidelberglaan 100 - 3584 CX Utrecht - Netherlands)
- University Medical Center [Utrecht] (Heidelberglaan 100 3584 CX Utrecht - Netherlands)
2
Department of Clinical Chemistry and Hematology [Utrecht, the Netherlands] ( Heidelberglaan 100 - 3584 CX Utrecht - Netherlands)
- University Medical Center [Utrecht] (Heidelberglaan 100 3584 CX Utrecht - Netherlands)
3
CRCNA - Centre de Recherche en Cancérologie Nantes-Angers (France)
- CHU Angers - Centre Hospitalier Universitaire d'Angers (4 rue Larrey - 49933 Angers cedex 9 - France)
- Hôtel-Dieu de Nantes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U892 (101, rue de Tolbiac, 75013 Paris - France)
- Hôpital Laennec (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6299 (France)
- Faculté de Médecine d'Angers (Rue Haute de Reculée 49045 Angers - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
4
CRCM - Centre de Recherche en Cancérologie de Marseille (27 bd Leï Roure, BP 300059
13273 Marseille Cedex 09 - France)
- AMU - Aix Marseille Université : UM105 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- Institut Paoli-Calmettes : UMR7258 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1068 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7258 (France)
5
Department of Medical Microbiology [Utrecht, the Netherlands] ( Heidelberglaan 100 - 3584 CX Utrecht - Netherlands)
- University Medical Center [Utrecht] (Heidelberglaan 100 3584 CX Utrecht - Netherlands)
6
VU University Amsterdam (De Boelelaan 1105, 1081 HV Amsterdam - Netherlands)
7
Department of Biochemistry and Molecular Biology [Illinois, USA] (Chicago, Illinois 60637 - United States)
- University of Chicago (Edward H. Levi Hall 5801 South Ellis Avenue Chicago, Illinois 60637 - United States)
Abstract : Highlights d Identification of SNPs near RhoB is associated with poor Vg9Vd2 T cell activation d RhoB activity and distribution in tumor cells modulate Vg9Vd2 T cell activation d Relocalization of RhoB induces membrane immobility of BTN3A1 d Tumor recognition by a Vg9Vd2 TCR depends on BTN3A1 conformation In Brief Sebestyen et al. show that Vg9Vd2TCR activation is modulated by the GTPase activity of RhoB in tumor cells, and by the relocalization of RhoB to BTN3A1. Subsequently, a phosphoantigen-induced conformational change in BTN3A1 leads to its recognition by Vg9Vd2TCRs.
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Journal articles
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https://www.hal.inserm.fr/inserm-01416269
Contributor : Elizabeth Bernardo <>
Submitted on : Wednesday, December 14, 2016 - 11:40:55 AM
Last modification on : Friday, July 30, 2021 - 3:22:03 AM
Long-term archiving on: : Wednesday, March 15, 2017 - 1:27:11 PM
Contributor : Elizabeth Bernardo <>
Submitted on : Wednesday, December 14, 2016 - 11:40:55 AM
Last modification on : Friday, July 30, 2021 - 3:22:03 AM
Long-term archiving on: : Wednesday, March 15, 2017 - 1:27:11 PM
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- HAL Id : inserm-01416269, version 1
- DOI : 10.1016/j.celrep.2016.04.081
Citation
Zsolt Sebestyen, Wouter Scheper, Anna Vyborova, Siyi Gu, Zuzana Rychnavska, et al.. RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor. Cell Reports, Elsevier Inc, 2016, 15, ⟨10.1016/j.celrep.2016.04.081⟩. ⟨inserm-01416269⟩
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