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Eukaryotic Ribosome as a Target for Cardiovascular Disease

Abstract : Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.
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https://www.hal.inserm.fr/inserm-01415698
Contributor : Gulnara Yusupova <>
Submitted on : Tuesday, December 13, 2016 - 2:47:25 PM
Last modification on : Thursday, April 23, 2020 - 2:26:27 PM
Long-term archiving on: : Tuesday, March 14, 2017 - 1:06:50 PM

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Simone Pellegrino, Gulnara Yusupova. Eukaryotic Ribosome as a Target for Cardiovascular Disease. Cell Chemical Biology, Cell Press, 2016, 17 (23), pp.1319-1321. ⟨10.1016/j.chembiol.2016.11.004⟩. ⟨inserm-01415698⟩

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