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Eukaryotic Ribosome as a Target for Cardiovascular Disease

Simone P Pellegrino 1, 2 Gulnara yusupova 1, * 
* Corresponding author
1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 Département de biologie structurale intégrée [Illkirch]
Abstract : Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.
Keywords : secreted protein translation ribosome ribosome inhibitor inhibitor cardiovascular deseases cardiovascular deseases secreted protein
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https://www.hal.inserm.fr/inserm-01415698
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Submitted on : Tuesday, December 13, 2016 - 2:47:25 PM
Last modification on : Tuesday, May 10, 2022 - 3:44:59 PM
Long-term archiving on: : Tuesday, March 14, 2017 - 1:06:50 PM

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Simone P Pellegrino, Gulnara yusupova. Eukaryotic Ribosome as a Target for Cardiovascular Disease. Cell Chemical Biology, Cell Press, 2016, 17 (23), pp.1319-1321. ⟨10.1016/j.chembiol.2016.11.004⟩. ⟨inserm-01415698⟩

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