Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorigenesis, Biochem. Pharmacol, pp.86-1643, 2013. ,
Drug discovery targeting epigenetic codes: The great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis, Biochemical Pharmacology, vol.78, issue.10, p.78, 2009. ,
DOI : 10.1016/j.bcp.2009.05.035
URL : https://hal.archives-ouvertes.fr/hal-00667244
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications, Epigenetics, vol.4, issue.1, pp.8-14, 2009. ,
DOI : 10.4161/epi.4.1.7370
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix, Nature, vol.54, issue.7214, pp.826-829, 2008. ,
DOI : 10.1038/nature07280
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism, Nature, vol.25, issue.7214, pp.818-821, 2008. ,
DOI : 10.1038/nature07249
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1, Nature, vol.39, issue.7214, pp.822-825, 2008. ,
DOI : 10.1038/nature07273
URL : https://hal.archives-ouvertes.fr/hal-00339497
DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination, Cell Research, vol.122, issue.8, 2015. ,
DOI : 10.1093/nar/gku316
UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold, Cell Rep, p.10, 2015. ,
DOI : 10.1016/j.celrep.2015.03.038
URL : http://doi.org/10.1016/j.celrep.2015.03.038
UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway, Cell Rep, p.10, 2015. ,
The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma, Molecular Carcinogenesis, vol.365, issue.2, 2015. ,
DOI : 10.1002/mc.22270
Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain, PLoS ONE, vol.23, issue.6, p.21306, 2011. ,
DOI : 10.1371/journal.pone.0021306.s010
Version 3, 2015. ,
Glide:?? A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy, Journal of Medicinal Chemistry, vol.47, issue.7, pp.47-1739, 2004. ,
DOI : 10.1021/jm0306430
Glide:?? A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening, Journal of Medicinal Chemistry, vol.47, issue.7, pp.47-1750, 2004. ,
DOI : 10.1021/jm030644s
Extra Precision Glide:?? Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein???Ligand Complexes, Journal of Medicinal Chemistry, vol.49, issue.21, pp.49-6177, 2006. ,
DOI : 10.1021/jm051256o
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability, Nature Protocols, vol.4, issue.9, pp.2212-2221, 2007. ,
DOI : 10.1038/nprot.2006.202
Enzymatic Analysis of Tet Proteins: Key Enzymes in the Metabolism of DNA Methylation, Methods Enzymol, vol.512, pp.93-105, 2002. ,
DOI : 10.1016/B978-0-12-391940-3.00005-6
A sensitive mass spectrometry method for simultaneous quantification of DNA methylation and hydroxymethylation levels in biological samples, Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay, pp.227-232, 2008. ,
DOI : 10.1016/j.ab.2011.01.026
Proximity ligation in situ assay for monitoring the global DNA methylation in cells, BMC Biotechnology, vol.11, issue.1, p.31, 2011. ,
DOI : 10.1364/OL.22.001905
URL : https://hal.archives-ouvertes.fr/inserm-00587414
Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells, PLoS ONE, vol.23, issue.6, p.11333, 2010. ,
DOI : 10.1371/journal.pone.0011333.s014
Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle, Cell Division, vol.7, issue.1, 2012. ,
DOI : 10.1364/OL.22.001905
URL : https://hal.archives-ouvertes.fr/inserm-00680687
Version 8, 2015. ,
UHRF1 discriminates against binding to fully-methylated CpG-Sites by steric repulsion, Biophysical Chemistry, vol.171, pp.171-209, 2013. ,
DOI : 10.1016/j.bpc.2012.10.002
Mechanism of DNA Methylation: The Double Role of DNA as a Substrate and as a Cofactor, Journal of Molecular Biology, vol.400, issue.3, pp.400-632, 2010. ,
DOI : 10.1016/j.jmb.2010.05.021
Importance of accurate charges in molecular docking: Quantum mechanical/molecular mechanical (QM/MM) approach, Journal of Computational Chemistry, vol.112, issue.9, pp.26-915, 2005. ,
DOI : 10.1002/jcc.20222