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Journal articles
A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides)
Tung Phan
1, 2
Brigitte Dreno
3, 4, *
Antonio Charlys da Costa
5, 2
Linlin Li
2, 1
Patricia Orlandi
6
Xutao Deng
2, 1
Beatrix Kapusinszky
2, 1
Juliana Siqueira
2, 7
Anne-Chantal Knol
3, 4
Franck Halary
8, 9
Jacques Dantal
10
Kathleen Alexander
11, 12
Patricia Pesavento
13
Eric Delwart
2, 1, *
*
Corresponding author
12
CARACAL
Tung A Phan 1, 2
Author
Brigitte Dreno 3, 4
Correspondent author
Antonio A Charlys da Costa 5, 2
Author
Linlin A Li 2, 1
Author
Patricia Orlandi 6
Author
Xutao A Deng 2, 1
Author
Beatrix A Kapusinszky 2, 1
Author
Juliana A Siqueira 2, 7
Author
Anne-Chantal A Knol 3, 4
Author
Franck Halary 8, 9
Author
Jacques Dantal 10
Author
Kathleen A Alexander 11, 12
Author
Patricia A Pesavento 13
Author
Eric A Delwart 2, 1
Correspondent author
1
Department of Laboratory Medicine [San Francisco] (UCSF - San Francisco, California, CA 94143-0560, USA - United States)
- UCSF - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)
- University of California (United States)
2
Blood Systems Research Institute (United States)
- UCSF - University of California [San Francisco] (505 Parnassus Ave, San Francisco, CA 94143 - United States)
- University of California (United States)
3
CRCNA - Centre de Recherche en Cancérologie Nantes-Angers (France)
- CHU Angers - Centre Hospitalier Universitaire d'Angers (4 rue Larrey - 49933 Angers cedex 9 - France)
- Hôtel-Dieu de Nantes (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U892 (101, rue de Tolbiac, 75013 Paris - France)
- Hôpital Laennec (France)
- CNRS - Centre National de la Recherche Scientifique : UMR6299 (France)
- Faculté de Médecine d'Angers (Rue Haute de Reculée 49045 Angers - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
4
Service de dermatologie [Nantes] (France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
5
ITM - Institute of Tropical Medicine [Antwerp] (Nationalestraat 155, 2000 Antwerp - Belgium)
6
FIOCRUZ - Fundação Oswaldo Cruz (Av. Brasil, 4365 - Manguinhos, Rio de Janeiro - Brazil)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
7
Instituto Nacional de Cancer (Rio de Janeiro - Brazil)
8
U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie (CHU Nantes - Hôtel Dieu - 30 Bd Jean Monnet 44093 Nantes Cedex 01. - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1064 (101, rue de Tolbiac, 75013 Paris - France)
- UFR MEDECINE - Université de Nantes - UFR de Médecine et des Techniques Médicales (1 rue Gaston Veil BP 53508 44035 NANTES Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
9
Service de Transplantation (France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
10
Service de Nephrologie (France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
11
Virginia Tech [Blacksburg] (Virginia Polytechnic Institute and State University Blacksburg, VA 24061-0002 - United States)
12
CARACAL (South Africa)
13
Department of Pathology Microbiology and Immunology, (United States)
- University of California (United States)
Abstract : We genetically characterized seven nearly complete genomes in the protoparvovirus genus from the feces of children with diarrhea. The viruses, provisionally named cutaviruses (CutaV), varied by 1–6% nucleotides and shared $ 76% and $ 82% amino acid identity with the NS1 and VP1 of human bufa-viruses, their closest relatives. Using PCR, cutavirus DNA was found in 1.6% (4/245) and 1% (1/100) of diarrhea samples from Brazil and Botswana respectively. In silico analysis of pre-existing metagenomics datasets then revealed closely related parvovirus genomes in skin biopsies from patients with epi-dermotropic cutaneous T-cell lymphoma (CTCL or mycosis fungoides). PCR of skin biopsies yielded cu-tavirus DNA in 4/17 CTCL, 0/10 skin carcinoma, and 0/21 normal or noncancerous skin biopsies. In situ hybridization of CTCL skin biopsies detected viral genome within rare individual cells in regions of neoplastic infiltrations. The influence of cutavirus infection on human enteric functions and possible oncolytic role in CTCL progression remain to be determined.
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https://www.hal.inserm.fr/inserm-01408880
Contributor : Elizabeth Bernardo <>
Submitted on : Monday, December 5, 2016 - 2:40:31 PM
Last modification on : Friday, July 30, 2021 - 3:16:29 AM
Long-term archiving on: : Tuesday, March 21, 2017 - 1:09:11 PM
Contributor : Elizabeth Bernardo <>
Submitted on : Monday, December 5, 2016 - 2:40:31 PM
Last modification on : Friday, July 30, 2021 - 3:16:29 AM
Long-term archiving on: : Tuesday, March 21, 2017 - 1:09:11 PM
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- HAL Id : inserm-01408880, version 1
- DOI : 10.1016/j.virol.2016.06.013
Citation
Tung Phan, Brigitte Dreno, Antonio Charlys da Costa, Linlin Li, Patricia Orlandi, et al.. A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides). Virology, Elsevier, 2016, 496, pp.299 - 305. ⟨10.1016/j.virol.2016.06.013⟩. ⟨inserm-01408880⟩
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