Abstract : Prokaryotes and eukaryotes evolved relatively similar RNA-based molecular mechanisms to fight potentially deleterious nucleic acids coming from phages, transposons, or viruses. Short RNAs guide effector complexes toward their targets to be silenced or eliminated. These short immunity RNAs are transcribed from clustered loci. Unexpectedly and strikingly, bacterial and eukaryotic immunity RNA clusters share substantial functional and mechanistic resemblances in fighting nucleic acid intruders.
https://www.hal.inserm.fr/inserm-01407781
Contributor : Annick Lefevre
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Submitted on : Thursday, December 13, 2018 - 10:33:56 AM
Last modification on : Thursday, December 13, 2018 - 11:32:10 AM
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Brice Felden, Luc Paillard. United we stand: Big roles for small RNA gene clusters. RNA, Cold Spring Harbor Laboratory Press, 2017, RNA, 23 (2), pp.131-133. ⟨10.1261/rna.058891.116⟩. ⟨inserm-01407781⟩
