Skip to Main content Skip to Navigation
Journal articles

Épidémiologie de l’infection à papillomavirus humains chez les femmes âgées de 20 à 65 ans résidant dans des communes isolées de Guyane française : adapter l’action au territoire

Abstract : Context – Cervical cancer is the second most frequent cancer of women in French Guiana. Studies have shown that populations living in remote villages in the interior of the territory have early sexual relations and that multiple sexual partnerships are frequent. Hence, the main objective of the study was to determine the prevalence of Human Papilloma Virus (HPV) in these areas. Methods – This multicentric cross sectional study was conducted in women aged 20 to 65 years, living in the remote villages along the Maroni and Oyapock rivers. Women were included on a voluntary basis after being informed of the study team schedule through radio address and key opinion leaders. The search for HPV and cytologic examinations were performed on each sample. HPV infection was defined by the detection of viral DNA using the Greiner Bio One® kit. Cytologic analyses were performed using the 2001 Bethesda classification. Results – Overall, 643 women were included in the study. Age-standardized HPV prevalence was 35%. The prevalence curve by age group showed a U-shaped pattern: women over 50 years had the highest risk of being infected by HPV, followed by women aged 20-29 years. In addition, 26.1% of women with a normal smear test had HPV infection. The most frequent genotypes were HPV52, HPV58, and HPV16. On interpretable smears 1.16% of women had high grade superficial intra-epithelial (HSIL) lesions. Conclusions – The standardized prevalence of HPV in French Guiana is among the highest in the world. HSIL cytological lesions were nearly 4 times more frequent than in the Île-de-France region. Given the importance of the incidence of cervical cancer in French Guiana, these results suggest it may be preferable to use HPV testing than cytology. Vaccination against HPV, preferably with the new nonavalent vaccine seems an appropriate prevention measure. However, this intervention will be a challenge to implement in this region where a significant proportion of the population is not covered by health insurance.
Document type :
Journal articles
Complete list of metadatas

Cited literature [26 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01407222
Contributor : Antoine Adenis <>
Submitted on : Thursday, December 1, 2016 - 7:32:22 PM
Last modification on : Thursday, September 17, 2020 - 3:43:04 PM
Long-term archiving on: : Monday, March 20, 2017 - 4:02:18 PM

File

2016, Dufit et al.pdf
Publisher files allowed on an open archive

Identifiers

  • HAL Id : inserm-01407222, version 1

Collections

Citation

Valentin Dufit, Antoine Adenis, Maylis Douine, Fatiha Najioullah, Odile Kilie, et al.. Épidémiologie de l’infection à papillomavirus humains chez les femmes âgées de 20 à 65 ans résidant dans des communes isolées de Guyane française : adapter l’action au territoire. Bulletin d'épidémiologie hebdomadaire, INVS, 2016, n°34, pp.588-597. ⟨inserm-01407222⟩

Share

Metrics

Record views

939

Files downloads

632