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Anti-viral Effect of Bifidobacterium adolescentis against Noroviruses

Abstract : This study aims to investigate the effect of Bifidobacterium adolescentis against noroviruses (NoVs). Murine norovirus-1 (MNV-1) used as a surrogate was detected by plaque assay and RT-qPCR. Human NoV virus like particles (VLPs) were detected by cell-binding assay. It was shown that the presence of B. adolescentis could inhibit the multiplication of MNV-1 on RAW 264.7 cells within 48 h of co-incubation period at 37 • C. This inhibition did not occur at the viral binding stage, as no difference was observed in MNV-1 genomic copies collected from washed RAW 264.7 cells without and with B. adolescentis after co-incubation for 1 h at room temperature. Meanwhile, the presence of B. adolescentis decreased the binding of human NoV GI.
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Submitted on : Thursday, December 1, 2016 - 8:36:19 AM
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Dan Li, Adrien Breiman, Jacques Le Pendu, Mieke Uyttendaele. Anti-viral Effect of Bifidobacterium adolescentis against Noroviruses. Frontiers in Microbiology, Frontiers Media, 2016, 7, pp.864. ⟨10.3389/fmicb.2016.00864⟩. ⟨inserm-01406298⟩



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