Control of asthma by omalizumab: the role of CD4(+) Foxp3(+) regulatory T cells.

Flore Amat; Pauline Tallon; Anne Perrine Foray; Bénédicte Michaud; Nathalie Lambert; Philippe Saint-Pierre; Lucienne Chatenoud; Jocelyne Just

doi:10.1111/cea.12839

Control of asthma by omalizumab: the role of CD4(+) Foxp3(+) regulatory T cells.

Flore Amat ^{1, 2} Pauline Tallon ² Anne Perrine Foray ³ Bénédicte Michaud ^{2, 3} Nathalie Lambert ^{2, 1} Philippe Saint-Pierre ^{1, 4} Lucienne Chatenoud ³ Jocelyne Just ²

1 Epidémiologie, Systèmes d'Information, Modélisation

2 Centre de l'Asthme et des Allergies [CHU Trousseau]

3 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades (INEM)

4 IMT - Institut de Mathématiques de Toulouse UMR5219

Abstract : Allergic asthma is an inflammatory disease of the airways, resulting from an inappropriate immune response to inhaled allergens, which involves multiple inflammatory cells and mediators that contribute to airway hyper-responsiveness. Omalizumab is a monoclonal antibody, specifically directed to the C-Epsilon3 domain of immunoglobulin E (IgE), indicated as an additional therapy in severe allergic asthma [1]. Impaired function of regulatory T cells (Treg) is incriminated in the aberrant asthma inflammatory response [2].

Type de document :

Article dans une revue

Clinical and Experimental Allergy, Wiley, 2016, Epub ahead of print. 〈10.1111/cea.12839〉

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-01404099
Contributeur : Flore Amat <>
Soumis le : lundi 28 novembre 2016 - 13:03:54
Dernière modification le : vendredi 14 septembre 2018 - 09:16:06

Control of asthma by omalizumab: the role of CD4(+) Foxp3(+) regulatory T cells.

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