 |
Journal articles
Control of asthma by omalizumab: the role of CD4(+) Foxp3(+) regulatory T cells.
Flore Amat
1, 2
Pauline Tallon
2
Anne Perrine Foray
3
Bénédicte Michaud
2, 3
Nathalie Lambert
2, 1
Philippe Saint-Pierre
1, 4
Lucienne Chatenoud
3
Jocelyne Just
2
Flore Amat 1, 2
Author Employer institution : CHU Trousseau [APHP]
Pauline Tallon 2
Author
Anne Perrine Foray 3
Author
Bénédicte Michaud 2, 3
Author
Nathalie Lambert 2, 1
Author
Philippe Saint-Pierre 1, 4
Author
Lucienne Chatenoud 3
Author
Jocelyne Just 2
Author
1
Epidémiologie, Systèmes d'Information, Modélisation (56 boulevard Vincent Auriol - BP 335 - 75625 Paris Cedex 13 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMRS1136 (101, rue de Tolbiac, 75013 Paris - France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
2
Centre de l'Asthme et des Allergies [CHU Trousseau] (26 Avenue du Docteur Arnold Netter, 75012 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Trousseau [APHP] (26 Avenue du Dr Arnold Netter, 75012 Paris - France)
3
INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades (Bâtiment Leriche
14 rue Maria Helena Vieira Da Silva
75014 Paris - France)
- UPD5 - Université Paris Descartes - Paris 5 : UM 111 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1151 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 8253 (France)
4
IMT - Institut de Mathématiques de Toulouse UMR5219 (UPS IMT, F-31062 Toulouse Cedex 9,
INSA Toulouse, F-31077 Toulouse,
France UT1, F-31042 Toulouse,
France UT2, F-31058 Toulouse,
Téléphone : 05.61.55.67.90 - France)
- INSA Toulouse - Institut National des Sciences Appliquées - Toulouse (135, avenue de Rangueil - 31077 Toulouse cedex 4 - France)
- UT1 - Université Toulouse 1 Capitole (2 rue du Doyen-Gabriel-Marty - 31042 Toulouse Cedex 9 - France)
- UT2J - Université Toulouse - Jean Jaurès (5 allées Antonio Machado - 31058 Toulouse Cedex 9 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5219 (France)
Abstract : Allergic asthma is an inflammatory disease of the airways, resulting from an inappropriate immune response to inhaled allergens, which involves multiple inflammatory cells and mediators that contribute to airway hyper-responsiveness. Omalizumab is a monoclonal antibody, specifically directed to the C-Epsilon3 domain of immunoglobulin E (IgE), indicated as an additional therapy in severe allergic asthma [1]. Impaired function of regulatory T cells (Treg) is incriminated in the aberrant asthma inflammatory response [2].
Document type :
Journal articles
Domain :
Complete list of metadatas
https://www.hal.inserm.fr/inserm-01404099
Contributor : Flore Amat <>
Submitted on : Monday, November 28, 2016 - 1:03:54 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:20 AM
Contributor : Flore Amat <>
Submitted on : Monday, November 28, 2016 - 1:03:54 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:20 AM
Links full text
Identifiers
- HAL Id : inserm-01404099, version 1
- DOI : 10.1111/cea.12839
- PUBMED : 27770456
Collections
CNRS | UPMC | UNIV-PARIS5 | USPC | IMT | UNIV-TLSE2 | SORBONNE-UNIVERSITE | UNIV-TLSE3 | UT1-CAPITOLE | INSA-TOULOUSE | INSA-GROUPE | UP-SANTE
Citation
Flore Amat, Pauline Tallon, Anne Perrine Foray, Bénédicte Michaud, Nathalie Lambert, et al.. Control of asthma by omalizumab: the role of CD4(+) Foxp3(+) regulatory T cells.. Clinical and Experimental Allergy, Wiley, 2016, Epub ahead of print. ⟨10.1111/cea.12839⟩. ⟨inserm-01404099⟩
Metrics
Record views