Clinical Features and Natural History of von Hippel-Lindau Disease, QJM, vol.77, issue.2, pp.1151-63, 1990. ,
DOI : 10.1093/qjmed/77.2.1151
von Hippel-Lindau disease, The Lancet, vol.361, issue.9374, pp.2059-67, 2003. ,
DOI : 10.1016/S0140-6736(03)13643-4
Von Hippel-Lindau disease, The Lancet, vol.363, issue.9416, pp.1231-1235, 2004. ,
DOI : 10.1016/S0140-6736(04)15957-6
URL : https://hal.archives-ouvertes.fr/inserm-01402348
Molecular basis of the VHL hereditary cancer syndrome, Nature Reviews Cancer, vol.2, pp.673-82, 2002. ,
Renal-Cell Carcinoma, New England Journal of Medicine, vol.353, issue.23, pp.2477-90, 2005. ,
DOI : 10.1056/NEJMra043172
Renal cell carcinoma, The Lancet, vol.373, issue.9669, pp.1119-1151, 2009. ,
DOI : 10.1016/S0140-6736(09)60229-4
The von Hippel?Lindau tumour suppressor protein: O2 sensing and cancer, Nature Reviews Cancer, vol.8, pp.865-73, 2008. ,
von Hippel???Lindau disease: A clinical and scientific review, European Journal of Human Genetics, vol.62, issue.6, pp.617-640, 2011. ,
DOI : 10.2174/1566524043359827
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110036
Central nervous system lesions in von Hippel-Lindau syndrome., Journal of Neurology, Neurosurgery & Psychiatry, vol.55, issue.10, pp.898-901, 1992. ,
DOI : 10.1136/jnnp.55.10.898
Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease, Neurosurgical Review, vol.23, issue.1, pp.1-22, 2000. ,
DOI : 10.1007/s101430050024
The natural history of hemangioblastomas of the central nervous system in patients with von Hippel???Lindau disease, Journal of Neurosurgery, vol.98, issue.1, pp.82-94, 2003. ,
DOI : 10.3171/jns.2003.98.1.0082
Edema is a precursor to central nervous system peritumoral cyst formation, Annals of Neurology, vol.136, issue.3, pp.392-401, 2005. ,
DOI : 10.1002/ana.20584
Management of von Hippel???Lindau disease-associated CNS lesions, Expert Review of Neurotherapeutics, vol.11, issue.10, pp.1433-1474, 2011. ,
DOI : 10.1586/ern.11.124
Clinical Characteristics of Ocular Angiomatosis in von Hippel-Lindau Disease and Correlation With Germline Mutation, Archives of Ophthalmology, vol.117, issue.3, pp.371-379, 1999. ,
DOI : 10.1001/archopht.117.3.371
Ocular manifestations in von Hippel?Lindau disease: a clinical and molecular study, Investigative Ophthalmology and Visual Science, vol.43, pp.3067-74, 2002. ,
Vitreoretinal Surgery for Severe Retinal Capillary Hemangiomas in Von Hippel???Lindau Disease, Ophthalmology, vol.118, issue.1, pp.142-151, 2011. ,
DOI : 10.1016/j.ophtha.2010.04.031
PREVALENCE, MORPHOLOGY AND BIOLOGY OF RENAL CELL CARCINOMA IN VON HIPPEL-LINDAU DISEASE COMPARED TO SPORADIC RENAL CELL CARCINOMA, The Journal of Urology, vol.160, issue.4, pp.1248-54, 1998. ,
DOI : 10.1016/S0022-5347(01)62509-6
Renal involvement in von Hippel-Lindau disease, Kidney International, vol.50, issue.3, pp.944-51, 1996. ,
DOI : 10.1038/ki.1996.395
Treatment of Renal Cell Carcinoma in Von Hippel-Lindau Disease: A Multicenter Study, The Journal of Urology, vol.153, issue.6, pp.1812-1818, 1995. ,
DOI : 10.1016/S0022-5347(01)67318-X
PARENCHYMAL SPARING SURGERY IN PATIENTS WITH HEREDITARY RENAL CELL CARCINOMA: 10-YEAR EXPERIENCE, The Journal of Urology, vol.165, issue.3, pp.777-81, 2001. ,
DOI : 10.1016/S0022-5347(05)66524-X
Nephron Sparing Surgery for Renal Cell Carcinoma and von Hippel-Lindau???s Disease: A Single Center Experience, The Journal of Urology, vol.170, issue.5, pp.1752-5811, 2003. ,
DOI : 10.1097/01.ju.0000092780.85876.de
THE RELATIONSHIP BETWEEN RENAL TUMOR SIZE AND METASTASES IN PATIENTS WITH VON HIPPEL-LINDAU DISEASE, The Journal of Urology, vol.172, issue.1, pp.63-68, 2004. ,
DOI : 10.1097/01.ju.0000132127.79974.3f
PERCUTANEOUS RENAL CRYOABLATION OF RENAL TUMORS IN PATIENTS WITH VON HIPPEL-LINDAU DISEASE, The Journal of Urology, vol.167, issue.3, pp.1268-70, 2002. ,
DOI : 10.1016/S0022-5347(05)65279-2
Probe ablation as salvage therapy for renal tumors in von Hippel-Lindau patients: The Cleveland Clinic experience with 3 years follow-up, Urologic Oncology: Seminars and Original Investigations, vol.31, issue.5, 2011. ,
DOI : 10.1016/j.urolonc.2011.05.008
Progress in Nephron Sparing Therapy for Renal Cell Carcinoma and von Hippel-Lindau Disease, The Journal of Urology, vol.185, issue.6, pp.2056-60, 2011. ,
DOI : 10.1016/j.juro.2011.02.007
RESULTS OF RENAL TRANSPLANTATION IN PATIENTS WITH RENAL CELL CARCINOMA AND VON HIPPEL-LINDAU DISEASE1,2, Transplantation, vol.64, issue.12, pp.1726-1735, 1997. ,
DOI : 10.1097/00007890-199712270-00017
Pheochromocytoma as the first manifestation of von Hippel?Lindau disease, Surgery, vol.116, pp.1076-81, 1994. ,
CLINICAL AND GENETIC CHARACTERIZATION OF PHEOCHROMOCYTOMA IN VON HIPPEL-LINDAU FAMILIES: COMPARISON WITH SPORADIC PHEOCHROMOCYTOMA GIVES INSIGHT INTO NATURAL HISTORY OF PHEOCHROMOCYTOMA, The Journal of Urology, vol.162, issue.3, pp.659-64, 1999. ,
DOI : 10.1097/00005392-199909010-00004
Head and Neck Paragangliomas in Von Hippel-Lindau Disease and Multiple Endocrine Neoplasia Type 2, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.6, pp.1938-1982, 2009. ,
DOI : 10.1210/jc.2009-0354
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690424
Pheochromocytomas in von Hippel-Lindau Syndrome and Multiple Endocrine Neoplasia Type 2 Display Distinct Biochemical and Clinical Phenotypes, The Journal of Clinical Endocrinology & Metabolism, vol.86, issue.5, pp.1999-2008, 2001. ,
DOI : 10.1210/jcem.86.5.7496
Plasma Normetanephrine and Metanephrine for Detecting Pheochromocytoma in von Hippel???Lindau Disease and Multiple Endocrine Neoplasia Type 2, New England Journal of Medicine, vol.340, issue.24, pp.1872-1881, 1999. ,
DOI : 10.1056/NEJM199906173402404
Pheochromocytomas and Paragangliomas in von Hippel???Lindau Disease, Archives of Surgery, vol.137, issue.6, pp.682-690, 2002. ,
DOI : 10.1001/archsurg.137.6.682
Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine tumors (PNETs), Surgery, vol.142, issue.6, pp.814-822, 2007. ,
DOI : 10.1016/j.surg.2007.09.012
Endocrine Pancreatic Tumors in von Hippel-Lindau Disease, Pancreas, vol.37, issue.1, pp.85-93, 2008. ,
DOI : 10.1097/MPA.0b013e31815f394a
Pancreatic involvement in von Hippel???Lindau disease, Pancreatic involvement in von Hippel?Lindau disease, pp.1087-95, 2000. ,
DOI : 10.1053/gast.2000.18143
Endolymphatic sac tumors. A source of morbid hearing loss in von Hippel-Lindau disease, JAMA: The Journal of the American Medical Association, vol.277, issue.18, pp.1461-1467, 1997. ,
DOI : 10.1001/jama.277.18.1461
Endolymphatic sac tumors in von Hippel???Lindau disease, Journal of Neurosurgery, vol.100, issue.3, pp.480-487, 2004. ,
DOI : 10.3171/jns.2004.100.3.0480
Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus, The Lancet, vol.337, issue.8749, pp.1052-1056, 1991. ,
DOI : 10.1016/0140-6736(91)91705-Y
Phenotypic expression in von Hippel-Lindau disease: correlations with germline VHL gene mutations., Journal of Medical Genetics, vol.33, issue.4, pp.328-360, 1996. ,
DOI : 10.1136/jmg.33.4.328
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1050584
Psychosocial impact of Von Hippel-Lindau disease: levels and sources of distress, Clinical Genetics, vol.288, issue.23, pp.483-91, 2010. ,
DOI : 10.1111/j.1399-0004.2010.01333.x
Von Hippel???Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma, Nature, vol.332, issue.6161, pp.268-277, 1988. ,
DOI : 10.1038/332268a0
Identification of the von Hippel-Lindau disease tumor suppressor gene, Science, vol.260, issue.5112, pp.1317-1337, 1993. ,
DOI : 10.1126/science.8493574
Gene Mutation in Human Cancer, Journal of Clinical Oncology, vol.22, issue.24, pp.4991-5004, 2004. ,
DOI : 10.1200/JCO.2004.05.061
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function, Science, vol.284, issue.5413, pp.455-61, 1999. ,
DOI : 10.1126/science.284.5413.455
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, vol.399, pp.271-276, 1999. ,
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway, Molecular Cell, vol.30, pp.393-402, 2008. ,
Ubiquitination of HIF requires direct binding to the von Hippel?Lindau protein domain, Nature Cell Biology, vol.2, pp.423-430, 2000. ,
HIFalpha Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing, Science, vol.292, issue.5516, pp.464-472, 2001. ,
DOI : 10.1126/science.1059817
Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation, Science, vol.292, issue.5516, pp.468-72, 2001. ,
DOI : 10.1126/science.1059796
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF, Science, vol.294, issue.5545, pp.1337-1377, 2001. ,
DOI : 10.1126/science.1066373
The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle, Science, vol.313, issue.5787, pp.629-662, 2006. ,
DOI : 10.1126/science.1124534
Role of Primary Cilia in the Pathogenesis of Polycystic Kidney Disease, Journal of the American Society of Nephrology, vol.18, issue.5, pp.1381-1389, 2007. ,
DOI : 10.1681/ASN.2006111215
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL, Nature Cell Biology, vol.10, issue.1, pp.64-70, 2003. ,
DOI : 10.1093/emboj/17.2.368
Formation of Primary Cilia in the Renal Epithelium Is Regulated by the von Hippel-Lindau Tumor Suppressor Protein, Journal of the American Society of Nephrology, vol.17, issue.7, pp.1801-1807, 2006. ,
DOI : 10.1681/ASN.2006020181
Primary Cilium Formation Requires von Hippel-Lindau Gene Function in Renal-Derived Cells, Cancer Research, vol.66, issue.14, pp.6903-6910, 2006. ,
DOI : 10.1158/0008-5472.CAN-06-0501
Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability, The Journal of Cell Biology, vol.23, issue.6, pp.991-1003, 2010. ,
DOI : 10.1083/jcb.201006059.dv
The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix, Molecular Cell, vol.1, issue.7, pp.959-68, 1998. ,
DOI : 10.1016/S1097-2765(00)80096-9
Collagen matrix assembly is driven by the interaction of von Hippel???Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2, Oncogene, vol.2, issue.7, pp.1004-1016, 2008. ,
DOI : 10.1128/MCB.24.8.3251-3261.2004
Role of the von Hippel?Lindau tumor suppressor gene in the formation of 1-integrin fibrillar adhesions, Cancer Research, vol.62, pp.2929-2965, 2002. ,
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer, Cancer Cell, vol.8, issue.2, pp.155-67, 2005. ,
DOI : 10.1016/j.ccr.2005.06.015
URL : http://doi.org/10.1016/j.ccr.2005.06.015
pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-??B Agonist Card9 by CK2, Molecular Cell, vol.28, issue.1, pp.15-27, 2007. ,
DOI : 10.1016/j.molcel.2007.09.010
p53 Stabilization and Transactivation by a von Hippel-Lindau Protein, Molecular Cell, vol.22, issue.3, pp.395-405, 2006. ,
DOI : 10.1016/j.molcel.2006.04.006
URL : http://doi.org/10.1016/j.molcel.2006.04.006
Phosphorylation of von Hippel-Lindau protein by checkpoint kinase 2 regulates p53 transactivation, Cell Cycle, vol.10, issue.22, pp.3920-3928, 2011. ,
DOI : 10.4161/cc.10.22.18096
Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma., Journal of Medical Genetics, vol.27, issue.5, pp.311-315, 1990. ,
DOI : 10.1136/jmg.27.5.311
Somatic inactivation of the VHL gene in von Hippel?Lindau disease tumours, American Journal of Human Genetics, vol.60, pp.765-71, 1997. ,
Tumour suppression by the human von Hippel-Lindau gene product, Nature Medicine, vol.162, issue.8, pp.822-828, 1995. ,
DOI : 10.1038/nm0895-822
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein, Cancer Cell, vol.1, issue.3, pp.237-283, 2002. ,
DOI : 10.1016/S1535-6108(02)00043-0
Mutations of the VHL tumour suppressor gene in renal carcinoma, Nature Genetics, vol.88, issue.1, pp.85-90, 1994. ,
DOI : 10.1038/ng0594-85
von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease, Human Pathology, vol.28, issue.5, pp.540-543, 1997. ,
DOI : 10.1016/S0046-8177(97)90075-7
von Hippel-Lindau Disease-Associated Hemangioblastomas Are Derived from Embryologic Multipotent Cells, PLoS Medicine, vol.209, issue.2, p.60, 2007. ,
DOI : 10.1371/journal.pmed.0040060.g005
URL : http://doi.org/10.1371/journal.pmed.0040060
HIF activation identifies early lesions in VHL kidneys, Cancer Cell, vol.1, issue.5, pp.459-68, 2002. ,
DOI : 10.1016/S1535-6108(02)00071-5
URL : http://doi.org/10.1016/s1535-6108(02)00071-5
VHL-gene Deletion in Single Renal Tubular Epithelial Cells and Renal Tubular Cysts: Further Evidence for a Cyst-dependent Progression Pathway of Clear Cell Renal Carcinoma in von Hippel-Lindau Disease, The American Journal of Surgical Pathology, vol.34, issue.6, pp.806-821, 2010. ,
DOI : 10.1097/PAS.0b013e3181ddf54d
The contribution of VHL substrate binding and HIF1-?? to the phenotype of VHL loss in renal cell carcinoma, Cancer Cell, vol.1, issue.3, pp.247-55, 2002. ,
DOI : 10.1016/S1535-6108(02)00044-2
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma, Molecular and Cellular Biology, vol.25, issue.13, pp.5675-86, 2005. ,
DOI : 10.1128/MCB.25.13.5675-5686.2005
Inhibition of HIF2?? Is Sufficient to Suppress pVHL-Defective Tumor Growth, PLoS Biology, vol.146, issue.3, p.83, 2003. ,
DOI : 10.1371/journal.pbio.0000083.g004
Role of VHL gene mutation in human cancer, Journal of Clinical Oncology, vol.22, pp.4991-5004, 2004. ,
Genetic and Epigenetic Analysis of von Hippel-Lindau (VHL) Gene Alterations and Relationship with Clinical Variables in Sporadic Renal Cancer, Cancer Research, vol.66, issue.4, pp.2000-2011, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-3074
Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney, Cancer Research, vol.69, issue.11, pp.4674-81, 2009. ,
DOI : 10.1158/0008-5472.CAN-09-0146
Copy number profiling in von hippel-lindau disease renal cell carcinoma, Genes, Chromosomes and Cancer, vol.70, issue.7, pp.479-88, 2011. ,
DOI : 10.1002/gcc.20865
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma, Nature, vol.133, issue.7331, pp.539-581, 2011. ,
DOI : 10.1038/nature09639
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma, Nature Genetics, vol.44, issue.1, pp.17-26, 2011. ,
DOI : 10.1146/annurev.med.042808.171650
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3, Nature Genetics, vol.2, issue.1, pp.60-65, 2011. ,
DOI : 10.1186/1471-2105-11-134
The kinesin KIF1B?? acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor, Genes & Development, vol.22, issue.7, pp.884-93, 2008. ,
DOI : 10.1101/gad.1648608
Genetic analysis of von Hippel?Lindau disease, Human Mutation, vol.31, pp.521-528, 2010. ,
Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan, Human Mutation, vol.25, issue.4, pp.348-57, 1996. ,
DOI : 10.1002/(SICI)1098-1004(1996)8:4<348::AID-HUMU8>3.0.CO;2-3
Germline mutation profile of the VHL gene in von Hippel???Lindau disease and in sporadic hemangioblastoma, Human Mutation, vol.12, issue.6, pp.424-454, 1998. ,
DOI : 10.1002/(SICI)1098-1004(1998)12:6<424::AID-HUMU9>3.3.CO;2-8
Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene, Human Mutation, vol.25, issue.6, pp.417-440, 1998. ,
DOI : 10.1002/(SICI)1098-1004(1998)12:6<417::AID-HUMU8>3.0.CO;2-K
Genotype-phenotype correlation in von Hippel-Lindau families with renal lesions, Human Mutation, vol.8, issue.1, pp.215-239, 2004. ,
DOI : 10.1002/humu.20082
Frequency of Von Hippel-Lindau germline mutations in classic and non-classic Von Hippel-Lindau disease identified by DNA sequencing, Southern blot analysis and multiplex ligation-dependent probe amplification, Clinical Genetics, vol.12, issue.2, pp.122-131, 2007. ,
DOI : 10.1111/j.1399-0004.2007.00827.x
Genotype-phenotype correlations in von Hippel-Lindau disease, Human Mutation, vol.8, issue.2, pp.143-152, 2007. ,
DOI : 10.1002/humu.20385
Software and database for the analysis of mutations in the VHL gene, Nucleic Acids Research, vol.26, issue.1, pp.256-264, 1998. ,
DOI : 10.1093/nar/26.1.256
Alu recombination underlies the vast majority of large VHL germline deletions: molecular characterization and correlations in VHL patients, Human Mutation, vol.30, pp.776-886, 2009. ,
Mosaicism in von Hippel???Lindau Disease: Lessons from Kindreds with Germline Mutations Identified in Offspring with Mosaic Parents, The American Journal of Human Genetics, vol.66, issue.1, pp.84-91, 2000. ,
DOI : 10.1086/302726
Germ-Line Mutations in Nonsyndromic Pheochromocytoma, New England Journal of Medicine, vol.346, issue.19, pp.1459-66, 2002. ,
DOI : 10.1056/NEJMoa020152
Cryptic von Hippel-Lindau disease: germline mutations in patients with haemangioblastoma only, Journal of Medical Genetics, vol.37, issue.12, pp.939-982, 2000. ,
DOI : 10.1136/jmg.37.12.939
Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany: evidence for a founder effect, Human Genetics, vol.95, issue.5, pp.551-557, 1995. ,
DOI : 10.1007/BF00223868
Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease, Human Molecular Genetics, vol.10, issue.10, pp.1029-1067, 2001. ,
DOI : 10.1093/hmg/10.10.1029
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF, Human Molecular Genetics, vol.10, issue.10, pp.1019-1046, 2001. ,
DOI : 10.1093/hmg/10.10.1019
Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients, Human Mutation, vol.8, issue.6, pp.613-634, 2007. ,
DOI : 10.1002/humu.20496
Genotype-Phenotype Correlation in Ocular von Hippel-Lindau (VHL) Disease: The Effect of Missense Mutation Position on Ocular VHL Phenotype, Investigative Opthalmology & Visual Science, vol.51, issue.9, pp.4464-70, 2010. ,
DOI : 10.1167/iovs.10-5223
An Analysis of Phenotypic Variation in the Familial Cancer Syndrome von Hippel???Lindau Disease: Evidence for Modifier Effects, The American Journal of Human Genetics, vol.63, issue.4, pp.1025-1060, 1998. ,
DOI : 10.1086/302037
Analysis of Germline Variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in Familial and Sporadic Renal Cell Carcinoma, PLoS ONE, vol.4, issue.6, p.6037, 2009. ,
DOI : 10.1371/journal.pone.0006037.t001
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia, Nature Genetics, vol.59, issue.4, pp.614-635, 2002. ,
DOI : 10.1016/0167-4889(90)90126-X
The worldwide distribution of the VHL 598C>T mutation indicates a single founding event, Blood, vol.103, issue.5, pp.1937-1977, 2004. ,
DOI : 10.1182/blood-2003-07-2550
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia, Nature Medicine, vol.90, issue.7, pp.845-54, 2011. ,
DOI : 10.1002/ajh.21381
Treatment of kidney cancer; insights provided by the VHL tumor-suppressor protein, Cancer, vol.115, pp.2262-72, 2009. ,
Hereditary kidney cancer, Cancer, vol.96, issue.suppl, pp.2252-61, 2009. ,
DOI : 10.1002/cncr.24230
Vascular Endothelial Growth Factor???Targeted Therapies in Advanced Renal Cell Carcinoma, Hematology/Oncology Clinics of North America, vol.25, issue.4, pp.813-846, 2011. ,
DOI : 10.1016/j.hoc.2011.04.006
Use of the Tyrosine Kinase Inhibitor Sunitinib in a Patient with von Hippel-Lindau Disease: Targeting Angiogenic Factors in Pheochromocytoma and Other von Hippel-Lindau Disease-Related Tumors, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.2, pp.386-91, 2009. ,
DOI : 10.1210/jc.2008-1972
Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416, Ophthalmology, vol.109, issue.9, pp.1745-51, 2002. ,
DOI : 10.1016/S0161-6420(02)01159-4
Treatment of von Hippel-Lindau retinal hemangioblastoma by the vascular endothelial growth factor receptor inhibitor SU5416 is more effective for associated macular edema than for hemangioblastomas, American Journal of Ophthalmology, vol.136, issue.1, pp.94-100, 2003. ,
DOI : 10.1016/S0002-9394(03)00101-6
Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy, Blood, vol.99, issue.10, pp.3851-3854, 2002. ,
DOI : 10.1182/blood.V99.10.3851
Antiangiogenic Therapy for von Hippel-Lindau Disease, JAMA: The Journal of the American Medical Association, vol.291, issue.8, pp.943-947, 2004. ,
DOI : 10.1001/jama.291.8.943
Intravitreal Ranibizumab Therapy for Retinal Capillary Hemangioblastoma Related to von Hippel-Lindau Disease, Ophthalmology, vol.115, issue.11, pp.1957-64, 2008. ,
DOI : 10.1016/j.ophtha.2008.04.033
URL : http://doi.org/10.1016/j.ophtha.2008.04.033
Pilot trial of sunitinib therapy in patients with von Hippel-Lindau disease, Annals of Oncology, vol.22, issue.12, pp.2661-2667, 2011. ,
DOI : 10.1093/annonc/mdr011
Overexpression and activation of epidermal growth factor receptor in hemangioblastomas, Journal of Neuro-Oncology, vol.318, issue.2, pp.195-200, 2010. ,
DOI : 10.1007/s11060-010-0125-9
HSP90 as a platform for the assembly of more effective cancer chemotherapy, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1823, issue.3, pp.756-66, 2012. ,
DOI : 10.1016/j.bbamcr.2011.12.006
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells, Proceedings of the National Academy of Sciences, vol.108, issue.50, pp.20048-53, 2011. ,
DOI : 10.1073/pnas.1114483108
Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen, Proceedings of the National Academy of Sciences, vol.105, issue.43, pp.16484-16493, 2008. ,
DOI : 10.1073/pnas.0806574105
Complex cellular functions of the von Hippel???Lindau tumor suppressor gene: insights from model organisms, Oncogene, vol.63, issue.18, pp.2247-57, 2012. ,
DOI : 10.1002/ajmg.1320490104
The VHL tumor suppressor in development and disease: Functional studies in mice by conditional gene targeting, Seminars in Cell & Developmental Biology, vol.16, issue.4-5, pp.564-74, 2005. ,
DOI : 10.1016/j.semcdb.2005.03.006
Renal Cyst Development in Mice with Conditional Inactivation of the von Hippel-Lindau Tumor Suppressor, Cancer Research, vol.66, issue.5, pp.2576-83, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-3241
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation, The EMBO Journal, vol.24, issue.12, pp.1747-57, 2008. ,
DOI : 10.1038/emboj.2008.96
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435131
Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1??, Cancer Research, vol.71, issue.21, pp.6848-56, 2011. ,
DOI : 10.1158/0008-5472.CAN-11-1745
Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations, PLoS ONE, vol.15, issue.4, p.4897, 2009. ,
DOI : 10.1371/journal.pone.0004897.s001