Skip to Main content Skip to Navigation
Journal articles

Low-Dose Pesticide Mixture Induces Senescence In Normal Mesenchymal Stem Cells (MSC) And Promotes Tumorigenic Phenotype In Premalignant MSC

Abstract : Humans are chronically exposed to multiple environmental pollutants such as pesticides with no significant evidence about the safety of such poly-exposures. We exposed mesenchymal stem cells (MSC) to very low doses of mixture of seven pesticides frequently detected in food samples for 21 days in vitro. We observed a permanent phenotype modification with a specific induction of an oxidative stress-related senescence. Pesticide mixture also induced a shift in MSC differentiation towards adipogenesis but did not initiate a tumorigenic transformation. In modified MSC in which a premalignant phenotype wasinduced, the exposure to pesticide mixture promoted tumorigenic phenotype both in vitro andin vivo after cell implantation, in all nude mice. Our results suggest that a commoncombination of pesticides can induce a premature ageing of adult MSC, and as such couldaccelerate age-related diseases. Exposure to pesticide mixture may also promote thetumorigenic transformation in a predisposed stromal environment.
Document type :
Journal articles
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01398601
Contributor : Elizabeth Bernardo <>
Submitted on : Thursday, November 17, 2016 - 2:53:10 PM
Last modification on : Friday, June 19, 2020 - 3:08:48 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

  • HAL Id : inserm-01398601, version 1

Collections

Citation

Mazène Hochane, Valérie Trichet, Claire Pecqueur, Pierre Avril, Lisa Oliver, et al.. Low-Dose Pesticide Mixture Induces Senescence In Normal Mesenchymal Stem Cells (MSC) And Promotes Tumorigenic Phenotype In Premalignant MSC. STEM CELLS, AlphaMed Press, 2016. ⟨inserm-01398601⟩

Share

Metrics

Record views

153