Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages

Abstract : Introduction: Mesothelioma is a rare and aggressive cancer related to asbestos exposure. We recently showed that pleural effusions (PEs) from patients with mesothelioma contain high levels of the CC motif chemokine ligand 2 (CCL2) inflammatory chemokine. In the present work, we studied the effect of CCL2 contained in mesothelioma samples , particularly on monocyte recruitment. Then, we studied the fate of these monocytes in malignant pleural mesotheli-oma (MPM) PEs and their impact on tumor cells' properties.
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Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2016, 11 (10), pp.1765 - 1773. 〈10.1016/j.jtho.2016.06.022〉
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Anne-Laure Chéné, Sènan D’almeida, Thibaut Blondy, Julie Tabiasco, Sophie Deshayes, et al.. Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages. Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2016, 11 (10), pp.1765 - 1773. 〈10.1016/j.jtho.2016.06.022〉. 〈inserm-01386814〉

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