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Nucleic acid ion structures in the gas phase

Abstract : Nucleic acids are diverse polymeric macromolecules that are essential for all life forms. These biomolecules possess functional three-dimensional structure under aqueous physiological conditions. Mass spectrometry-based approaches have on the other hand opened the possibility to gain structural information on nucleic acids from gas-phase measurements. To correlate gas-phase structural probing results to solution structures, it is therefore important to grasp the extent to which nucleic acid structures are preserved, or altered, when transferred from the solution to a fully anhydrous environment. We will review here experimental and theoretical approaches available to characterize the structure of nucleic acids in the gas phase (with a focus on oligonucleotides and higher-order structures), and will summarize the structural features of nucleic acids that can be preserved in the gas phase on the experiment time scale.
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Submitted on : Saturday, October 22, 2016 - 1:30:46 PM
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Josephine Abi-Ghanem, Valérie Gabelica. Nucleic acid ion structures in the gas phase. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16 (39), pp.21204 - 21218. ⟨10.1039/C4CP02362E⟩. ⟨inserm-01385789⟩

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