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Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures

Jun Zhou 1 Dursun Nizam Korkut 1 Frédéric Rosu 2 Samir Amrane 1 Valérie Gabelica 1, * Jean-Louis Mergny 1, *
* Corresponding author
1 ARNA - Régulations Naturelles et Artificielles
2 Soutien à la Recherche de l'Institut Européen de Chimie Biologique
Abstract : In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modifications. We hope this paper will guide others as they perform similar experiments leading to more information about the effects of chemical modifications on G-quadruplex formation. The structures of tetramolecular quadruplexes and some higher order structures based on tetramolecular quadruplexes are also described.
Keywords : G-quadruplex chemical modification UV CD NMR Review article Mass spectrometry
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Jun Zhou, Dursun Nizam Korkut, Frédéric Rosu, Samir Amrane, Valérie Gabelica, et al.. Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures. Methods, Elsevier, 2014, Nucleic Acids Nanotechnology, 67, pp.159 - 168. ⟨10.1016/j.ymeth.2014.01.004⟩. ⟨inserm-01385785⟩

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