HOIL1 cleavage by MALT1, the knives are out - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Receptors & Clinical Investigation Year : 2016

HOIL1 cleavage by MALT1, the knives are out

Abstract

The paracaspase MALT1 functions as a bifunctional regulator of lymphocyte activation following the engagement of antigen receptors. First, MALT1 scaffolds the CARMA1-BCL10-MALT1 (CBM) signaling complex in charge of activating the NF-κB transcription factor. Second, MALT1 proteolytic activity governs NF-κB fine-tuning and the homeostasis of the immune system. MALT1 is also constitutively activated in the activated B-cell like (ABC) subset of diffuse large B-cell lymphoma (DLBCL), and the discovery that its chemical inhibition is toxic has opened new perspectives of treatment. Yet, the nature of MALT1 substrates continues to be elucidated. Herein, we review the recent identification of the linear ubiquitin assembly chain complex (LUBAC) element HOIL1 as a new substrate for MALT1 in lymphocytes and lymphoma. We discuss how this processing may affect NF-κB signaling and impact on lymphocyte homeostasis.

Domains

Cancer
Fichier principal
Vignette du fichier
1410-8529-2-PBEqu15.pdf (188.89 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-01385207 , version 1 (21-10-2016)

Identifiers

Cite

Tiphaine Douanne, Nicolas Bidère. HOIL1 cleavage by MALT1, the knives are out. Receptors & Clinical Investigation, 2016, 3, pp.1410. ⟨10.14800/rci.1410⟩. ⟨inserm-01385207⟩
98 View
200 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More