A Lack of Clinical Effect of High-frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double-blind Trial

Aurélia Gay 1, 2 Isabelle Jaussent 3 Torrance Sigaud 1, 2 Stéphane Billard 1 Jérôme Attal 4, 3 Maude Sénèque 3, 5 Bogdan Galusca 2 Frederique Van den Eynde 6 Massoubre Catherine 1, 2 Philippe Courtet 3, 5 Sebastien Guillaume 3, 5, *
* Auteur correspondant
1 Département de psychiatrie et d'addictologie [CHU Saint-Etienne]
2 TAPE laboratory [Saint-Étienne]
3 Neuropsychiatrie : recherche épidémiologique et clinique
4 Département de psychiatrie adulte
5 Département d'urgences et post urgences psychiatriques [CHRU Montpellier]
6 Department of Psychiatry [Montréal]
Abstract : Studies suggests that stimulation of the left dorsolateral prefrontal cortex (DLPFC) reduces food craving in bulimic patients, but evidence supporting rTMS as a therapeutic tool is lacking. We investigated the safety and therapeutic efficacy of an adjunct high-frequency rTMS program targeting the left DLPFC. Forty-seven females with bulimia nervosa were randomised to a real or sham stimulation group. The real group underwent ten rTMS sessions, each consisting of 20 trains of 5 seconds with 55-second intervals between trains, at a frequency of 10 Hz. The main outcome was the number of binge episodes in the 15 days following the end of stimulation. Overall, no significant improvement in binging and purging symptoms was noted after the program. rTMS was well tolerated. This suggests that ten sessions of high-frequency rTMS to the left DLPFC provide no greater benefit than placebo. Future studies should consider methodological issues as well as alternative targets.
Keywords : neuromodulation bulimia nervosa craving eating disorders
Type de document :
Article dans une revue
European Eating Disorders Review, Wiley, 2016, 24 (6), pp.474-481. 〈10.1002/erv.2475〉
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https://www.hal.inserm.fr/inserm-01382734
Contributeur : Maude Seneque <>
Soumis le : lundi 17 octobre 2016 - 14:49:21
Dernière modification le : jeudi 7 février 2019 - 16:07:18

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rTMS_SebastienGUILLAUME.pdf

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U1061 | UNIV-ST-ETIENNE | BS | UNIV-MONTPELLIER

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Aurélia Gay, Isabelle Jaussent, Torrance Sigaud, Stéphane Billard, Jérôme Attal, et al.. A Lack of Clinical Effect of High-frequency rTMS to Dorsolateral Prefrontal Cortex on Bulimic Symptoms: A Randomised, Double-blind Trial. European Eating Disorders Review, Wiley, 2016, 24 (6), pp.474-481. 〈10.1002/erv.2475〉. 〈inserm-01382734〉

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