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Spitting out the demons: Extracellular vesicles in glioblastoma

Gwennan André-Grégoire 1 Julie Gavard 1, *
* Corresponding author
1 CRCINA-ÉQUIPE 15 - Signaling in Oncogenesis, Angiogenesis and Permeability
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Discovered decades ago, extracellular vesicles (EVs) emerge as dedicated organelles, able to deliver protected, specific cellular cues throughout the organism. While virtually every cell can release EVs, cancer cells co-opted this feature and efficiently unleashed them both in the tumor microenvironment and towards healthy tissues. This might contribute to tumor aggressiveness and spreading. Cancer-derived EVs that contain DNA, mRNA, miRNA, and packed and transmembrane proteins can operate locally or at distance. This review will focus on the high-grade brain tumor (i.e. glioblastoma)-derived EVs, discussing recent reports on i) their phenotype and content, ii) their putative functions, and iii) their clinical potential for improving diagnosis and therapeutics.
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Submitted on : Monday, October 17, 2016 - 9:18:34 AM
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Gwennan André-Grégoire, Julie Gavard. Spitting out the demons: Extracellular vesicles in glioblastoma. Cell Adhesion and Migration, Taylor & Francis, 2016, 11 (2), pp.164-172. ⟨10.1080/19336918.2016.1247145⟩. ⟨inserm-01382405⟩

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