Perip7lakin is a target for autoimmunity in asthma

Abstract : AbstractThe role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients.
Type de document :
Article dans une revue
Respiratory Research, BioMed Central, 2016, 17 (1), pp.126. 〈10.1186/s12931-016-0441-5〉
Liste complète des métadonnées

Littérature citée [11 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01377406
Contributeur : Bmc Bmc <>
Soumis le : vendredi 7 octobre 2016 - 08:04:03
Dernière modification le : vendredi 1 juin 2018 - 18:16:06
Document(s) archivé(s) le : dimanche 8 janvier 2017 - 12:25:07

Fichier

12931_2016_Article_441.pdf
Publication financée par une institution

Identifiants

Collections

Citation

Camille Taillé, Sabine Grootenboer-Mignot, Candice Estellat, Carine Roy, Sophie Ly Ka So, et al.. Perip7lakin is a target for autoimmunity in asthma. Respiratory Research, BioMed Central, 2016, 17 (1), pp.126. 〈10.1186/s12931-016-0441-5〉. 〈inserm-01377406〉

Partager

Métriques

Consultations de la notice

143

Téléchargements de fichiers

27