Awake hippocampal reactivations project onto orthogonal neuronal assemblies

Abstract : The chained activation of neuronal assemblies is thought to support major cognitive processes, including memory. In the hippocampus, this is observed during population bursts often associated with sharp-wave ripples, in the form of an ordered reactivation of neurons. However, the organization and lifetime of these assemblies remain unknown.We used calcium imaging to map patterns of synchronous neuronal activation in the CA1 region of awakemice during runs on a treadmill.The patterns were composed of the recurring activation of anatomically intermingled, but functionally orthogonal, assemblies.These assemblies reactivated discrete temporal segments of neuronal sequences observed during runs and could be stable across consecutive days. A binding of these assemblies into longer chains revealed temporally ordered replay.
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Rosa Cossart, Malvache Arnaud, Reichinnek Susanne, Villette Vincent, Haimerl Caroline. Awake hippocampal reactivations project onto orthogonal neuronal assemblies . Science, American Association for the Advancement of Science, 2016, 353 ((6305)), pp.1280-3. ⟨10.1126/science.aaf3319⟩. ⟨inserm-01375422⟩

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