Awake hippocampal reactivations project onto orthogonal neuronal assemblies

Abstract : The chained activation of neuronal assemblies is thought to support major cognitive processes, including memory. In the hippocampus, this is observed during population bursts often associated with sharp-wave ripples, in the form of an ordered reactivation of neurons. However, the organization and lifetime of these assemblies remain unknown.We used calcium imaging to map patterns of synchronous neuronal activation in the CA1 region of awakemice during runs on a treadmill.The patterns were composed of the recurring activation of anatomically intermingled, but functionally orthogonal, assemblies.These assemblies reactivated discrete temporal segments of neuronal sequences observed during runs and could be stable across consecutive days. A binding of these assemblies into longer chains revealed temporally ordered replay.
Type de document :
Article dans une revue
Science, American Association for the Advancement of Science, 2016, 353 ((6305)), pp.1280-3. 〈10.1126/science.aaf3319〉
Liste complète des métadonnées

Littérature citée [35 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01375422
Contributeur : Rosa Cossart <>
Soumis le : lundi 3 octobre 2016 - 10:59:56
Dernière modification le : vendredi 2 février 2018 - 01:22:35
Document(s) archivé(s) le : vendredi 3 février 2017 - 14:07:04

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Rosa Cossart, Malvache Arnaud, Reichinnek Susanne, Villette Vincent, Haimerl Caroline. Awake hippocampal reactivations project onto orthogonal neuronal assemblies . Science, American Association for the Advancement of Science, 2016, 353 ((6305)), pp.1280-3. 〈10.1126/science.aaf3319〉. 〈inserm-01375422〉

Partager

Métriques

Consultations de la notice

131