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Journal articles
Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery
Laurence Ardouin
1
Hervé Luche
1, 2
Rabie Chelbi
1
Sabrina Carpentier
3
Alaa Shawket
1
Frédéric Montañana-Sanchis
1
Camille Santa Maria
2
Pierre Grenot
2
Yannick Alexandre
1, 4
Claude Grégoire
1
Anissa Fries
1
Thien-Phong Vu Manh
1
Samira Tamoutounour
1
Karine Crozat
1
Elena Tomasello
1
Audrey Jorquera
1
Even Fossum
5
Bjarne Bogen
5
Hiroaki Azukizawa
6
Marc Bajenoff
1
Sandrine Henri
1
Marc Dalod
1, *
Bernard Malissen
2, 1, *
*
Corresponding author
Alaa Shawket 1
Author
Frédéric Montañana-Sanchis 1
Author
Camille Santa Maria 2
Author
Pierre Grenot 2
Author
Yannick Alexandre 1, 4
Author
Claude Grégoire 1
Author
Anissa Fries 1
Author
Thien-Phong Vu Manh 1
Author IdHAL : thien-phong-vu-manh ORCID : https://orcid.org/0000-0002-0294-342X
Samira Tamoutounour 1
Author
Karine Crozat 1
Author IdHAL : karine-crozat ResearcherId : http://www.researcherid.com/rid/L-7297-2019 ORCID : https://orcid.org/0000-0003-4761-3675
Elena Tomasello 1
Author
Audrey Jorquera 1
Author
Even Fossum 5
Author
Bjarne Bogen 5
Author
Hiroaki Azukizawa 6
Author
Marc Bajenoff 1
Author IdHAL : marc-bajenoff
Sandrine Henri 1
Author
Marc Dalod 1
Correspondent author IdHAL : marc-dalod
Bernard Malissen 2, 1
Correspondent author IdHAL : bernard-malissen IdRef : https://www.idref.fr/03049690X VIAF : https://viaf.org/viaf/14815643 ISNI : http://isni.org/isni/0000000028252593
1
CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France)
- AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7280 (France)
2
CIPHE - Centre d'Immunophénomique (Parc Scientifique et Technologique de Luminy - 163 avenue de Luminy - Case 936 - 13288 Marseille Cedex 9 - France)
- AMU - Aix Marseille Université : US012 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : US012 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMS3367 (France)
3
Mi-mAbs (C/O CIML) (France)
- CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France)
- AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7280 (France)
4
VIM (UR 0892) - Unité de recherche Virologie et Immunologie Moléculaires (INRA Centre de Recherche de Jouy-en-Josas F-78352 Jouy-en-Josas cedex - France)
- INRA - Institut National de la Recherche Agronomique : UR0892 (France)
5
CIR - Center for Immune Regulation [Oslo] (Norway)
- Faculty of Medicine [Oslo] (PO BOX 1078 Blindern, 0316 Oslo - Norway)
- UiO - University of Oslo (P.O 1072 Blindern 0316 Oslo - Norway)
- Rigshospitalet [Copenhagen] (Blegdamsvej 9
2100 Copenhagen - Denmark)
- Copenhagen University Hospital (Denmark)
6
Department of Dermatology [Osaka, Japan] (1-1 Yamadaoka, Suita, Osaka Prefecture 565-0871 - Japan)
- Osaka University [Japan] (1-1 Yamadaoka, Suita, Osaka Prefecture 565-0871 - Japan)
Abstract : Dendritic cells (DCs) are instrumental in the initiation of T cell responses, but how thymic and peripheral tolerogenic DCs differ globally from Toll-like receptor (TLR)-induced immunogenic DCs remains unclear. Here, we show that thymic XCR1(+) DCs undergo a high rate of maturation, accompanied by profound gene-expression changes that are essential for central tolerance and also happen in germ-free mice. Those changes largely overlap those occurring during tolerogenic and, more unexpectedly, TLR-induced maturation of peripheral XCR1(+) DCs, arguing against the commonly held view that tolerogenic DCs undergo incomplete maturation. Interferon-stimulated gene (ISG) expression was among the few discriminators of immunogenic and tolerogenic XCR1(+) DCs. Tolerogenic XCR1(+) thymic DCs were, however, unique in expressing ISGs known to restrain virus replication. Therefore, a broad functional convergence characterizes tolerogenic and immunogenic XCR1(+) DC maturation in the thymus and periphery, maximizing antigen presentation and signal delivery to developing and to conventional and regulatory mature T cells.
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Journal articles
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https://www.hal.inserm.fr/inserm-01374574
Contributor : Sandrine Henri <>
Submitted on : Tuesday, October 4, 2016 - 2:00:35 PM
Last modification on : Monday, March 29, 2021 - 2:42:32 PM
Long-term archiving on: : Friday, February 3, 2017 - 3:43:25 PM
Contributor : Sandrine Henri <>
Submitted on : Tuesday, October 4, 2016 - 2:00:35 PM
Last modification on : Monday, March 29, 2021 - 2:42:32 PM
Long-term archiving on: : Friday, February 3, 2017 - 3:43:25 PM
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Identifiers
- HAL Id : inserm-01374574, version 1
- DOI : 10.1016/j.immuni.2016.07.019
- PUBMED : 27533013
Citation
Laurence Ardouin, Hervé Luche, Rabie Chelbi, Sabrina Carpentier, Alaa Shawket, et al.. Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery. Immunity, Elsevier, 2016, 45 ((2)), pp.305-18. ⟨10.1016/j.immuni.2016.07.019⟩. ⟨inserm-01374574⟩
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