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Journal articles
Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis
Abstract : AbstractThe activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge. In contrast the level of the cysteine cathepsin inhibitor cystatin C was unaffected in BALF of wild-type and cathepsin B-deficient mice. Therefore, murine cystatin C is not a reliable marker of fibrosis during bleomycin-induced lung fibrosis. Current data are in sharp contrast to previous analysis carried on human BALF from patients with idiopathic pulmonary fibrosis, for which the level of cathepsin B remained unchanged while cystatin C was significantly increased.
Cited literature [17 references]
https://www.hal.inserm.fr/inserm-01370616
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Submitted on : Friday, September 23, 2016 - 8:03:05 AM
Last modification on : Thursday, August 20, 2020 - 12:00:17 PM
Contributor : Bmc Bmc <>
Submitted on : Friday, September 23, 2016 - 8:03:05 AM
Last modification on : Thursday, August 20, 2020 - 12:00:17 PM
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12931_2016_Article_432.pdf
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