Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis

Mariana Kasabova 1 Bérengère Villeret 2 Aurélie Gombault 2 Fabien Lecaille 1 Thomas Reinheckel 3 Sylvain Marchand-Adam 4, 1 Isabelle Couillin 2 Gilles Lalmanach 1, *
* Auteur correspondant
1 Pathologies Respiratoires : Protéolyse et Aérosolthérapie
2 INEM - Immunologie et Neurogénétique Expérimentales et Moléculaires
3 ZBMZ - Institute of Molecular Medicine and Cell Research
4 Service de Pneumologie [Tours]
Abstract : AbstractThe activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge. In contrast the level of the cysteine cathepsin inhibitor cystatin C was unaffected in BALF of wild-type and cathepsin B-deficient mice. Therefore, murine cystatin C is not a reliable marker of fibrosis during bleomycin-induced lung fibrosis. Current data are in sharp contrast to previous analysis carried on human BALF from patients with idiopathic pulmonary fibrosis, for which the level of cathepsin B remained unchanged while cystatin C was significantly increased.
Keywords : Lung Cathepsins Cystatins Fibrosis Bronchoalveolar lavage fluid Bleomycin Proteases
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Respiratory Research, BioMed Central, 2015, 17 (1), pp.118. 〈10.1186/s12931-016-0432-6〉
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Mariana Kasabova, Bérengère Villeret, Aurélie Gombault, Fabien Lecaille, Thomas Reinheckel, et al.. Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis. Respiratory Research, BioMed Central, 2015, 17 (1), pp.118. 〈10.1186/s12931-016-0432-6〉. 〈inserm-01370616〉

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