Hypoglycaemia revealing heterozygous insulin receptor mutations.

Vanessa Preumont 1 Christine Feincoeur 1 Olivier Lascols 2, 3, 4 Carine Courtillot 4, 5, 6, 7, 2 Philippe Touraine 4, 5, 6, 7, 2 Dominique Maiter 1 Corinne Vigouroux 3, 4, 2, *
* Auteur correspondant
1 Department of Endocrinology and Nutrition [Bruxelles, Belgium]
2 Sorbonne Universités
3 CR Saint-Antoine - Centre de Recherche Saint-Antoine
4 UPMC - Université Pierre et Marie Curie - Paris 6
5 Centre des Pathologies gynécologiques Rares [CHU Pitié-Salpêtrière]
6 Institut E3M [CHU Pitié-Salpêtrière]
7 Service d'endocrinologie et de la médecine reproductive [CHU Pitié-Salpêtrière]
Abstract : Major hyperinsulinemia, acanthosis nigricans, impaired glucose tolerance and ovarian hyperandrogenism characterize Type A insulin resistance (IR) syndrome due to dominant-negative heterozygous mutations in the insulin receptor gene (INSR). However, two unrelated families have been described with symptomatic hypoglycemia due to heterozygous INSR p.Arg1201 substitutions in the tyrosine kinase domain. In these patients, major hyperinsulinemia together with decreased insulin clearance was suggested to rescue genetically-altered insulin signalling in vivo in liver and/or muscle. We broaden the genetic spectrum of this rare phenotype of Type A insulin resistance by reporting the observations of two patients with INSR p.Met1180Val or p.Arg1201Gln heterozygous mutations revealed by repeated symptomatic hypoglycemia. Our observations further demonstrate that hyperinsulinemic hypoglycemia in adults can reveal different heterozygous mutations in the insulin receptor tyrosine kinase domain, whether associated or not with acanthosis nigricans, impaired glucose tolerance and/or ovarian hyperandrogenism.
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Diabetes and Metabolism, Elsevier Masson, 2016, 43 (1), pp.95-96. 〈10.1016/j.diabet.2016.07.001〉
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Soumis le : mardi 20 septembre 2016 - 18:11:02
Dernière modification le : vendredi 31 août 2018 - 09:13:21

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Vanessa Preumont, Christine Feincoeur, Olivier Lascols, Carine Courtillot, Philippe Touraine, et al.. Hypoglycaemia revealing heterozygous insulin receptor mutations.. Diabetes and Metabolism, Elsevier Masson, 2016, 43 (1), pp.95-96. 〈10.1016/j.diabet.2016.07.001〉. 〈inserm-01369327〉

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