Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

Arnaud Chêne 1, 2 Sophie Houard 3 Morten Nielsen 4, 5 Sophia Hundt 3 Flavia D 'Alessio 3 Sodiomon Sirima 6 Adrian Luty 7 Patrick Duffy 8 Odile Leroy 3 Benoit Gamain 1, 2 Nicola Viebig 3, *
* Auteur correspondant
1 BIGR - Biologie Intégrée du Globule Rouge
2 USPC - Université Sorbonne Paris Cité
3 European Vaccine Initiative [Heidelberg, Germany]
4 Department of Infectious Diseases [Copenhagen]
5 Centre for Medical Parasitology at Department of Immunology and Microbiology [Copenhagen, Denmark]
6 Development and integration of the country’s malaria control programme [Ouagadougou, Burkina Faso]
7 MERIT - UMR_D 216 - Mère et enfant face aux infections tropicales
8 Laboratory of Malaria Immunologyand Vaccinology [Rockville, MD, USA]
Abstract : Placental malaria caused by Plasmodium falciparum infection constitutes a major health problem manifesting as severe disease and anaemia in the mother, impaired fetal development, low birth weight or spontaneous abortion. Prevention of placental malaria currently relies on two key strategies that are losing efficacy due to spread of resistance: long-lasting insecticide-treated nets and intermittent preventive treatment during pregnancy. A placental malaria vaccine would be an attractive, cost-effective complement to the existing control tools. Two placental malaria vaccine candidates are currently in Phase Ia/b clinical trials. During two workshops hosted by the European Vaccine Initiative, one in Paris in April 2014 and the other in Brussels in November 2014, the main actors in placental malaria vaccine research discussed the harmonization of clinical development plans and of the immunoassays with a goal to define standards that will allow comparative assessment of different placental malaria vaccine candidates. The recommendations of these workshops should guide researchers and clinicians in the further development of placental malaria vaccines.
Keywords : Immunoassays Harmonization Placental malaria Vaccine development Clinical trial
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Malaria Journal, BioMed Central, 2016, 15 (1), pp.476. 〈10.1186/s12936-016-1527-8〉
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Arnaud Chêne, Sophie Houard, Morten Nielsen, Sophia Hundt, Flavia D 'Alessio, et al.. Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report. Malaria Journal, BioMed Central, 2016, 15 (1), pp.476. 〈10.1186/s12936-016-1527-8〉. 〈inserm-01367962〉

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