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Nutrition and mortality in the elderly over 10 years of follow-up: the Three-City study : Nutrition and mortality

Abstract : In the last 20 years, many prospective cohort studies have assessed the relationships between food consumption and mortality. Result interpretation is mainly hindered by the limited adjustment for confounders and, to a lesser extent, the small sample sizes. The aim of this study was to investigate the association between dietary habits and all-cause mortality in a multicentre prospective cohort that included non-institutionalised, community-based elderly individuals (Three-City Study). A brief FFQ was administered at baseline. Hazard ratios (HR) and 95 % CI for all-cause mortality were estimated relative to the consumption frequency of several food groups, using Cox proportional hazards models adjusted for sex, centre, socio-demographic characteristics and health status indicators. Among the 8937 participants (mean age: 74•2 years, 60•7 % women), 2016 deaths were recorded during an average follow-up of 9 years. The risk of death was significantly lower among subjects with the highest fruit and vegetable consumption (HR 0•90; 95 % CI 0•82, 0•99, P=0•03) and with regular fish consumption (HR 0•89; 95 % CI 0•81, 0•97, P=0•01). The benefit of olive oil use was found only in women (moderate olive oil use: HR 0•80; 95 % CI 0•68, 0•94, P=0•007; intensive use: HR 0•72; 95 % CI 0•60, 0•85, P=0•0002). Conversely, daily meat consumption increased the mortality risk (HR 1•12; 95 % CI, 1•01, 1•24, P=0•03). No association was found between risk of death and diet diversity and use of various fats. These findings suggest that fruits/vegetables, olive oil and regular fish consumptions have a beneficial effect on the risk of death, independently of the socio-demographic features and the number of medical conditions.
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Submitted on : Tuesday, August 23, 2016 - 10:32:08 AM
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Flavie Letois, Thibault Mura, Jacqueline Scali, Laure-Anne Gutierrez, Catherine Feart, et al.. Nutrition and mortality in the elderly over 10 years of follow-up: the Three-City study : Nutrition and mortality. British Journal of Nutrition, Cambridge University Press (CUP), 2016, 116 (5), pp.882-9. ⟨10.1017/S000711451600266X⟩. ⟨inserm-01355378⟩



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