L. G. Griffith and M. Swartz, Capturing complex 3D tissue physiology in vitro, Nature Reviews Molecular Cell Biology, vol.263, issue.3, pp.211-235, 2006.
DOI : 10.1038/nrm1858

T. E. Decoursey, Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family, Physiological Reviews, vol.93, issue.2, pp.599-652, 2013.
DOI : 10.1152/physrev.00011.2012

A. Lardner, The effects of extracellular pH on immune function, J. Leukoc. Biol, vol.69, pp.522-530, 2001.

J. Wemmie, M. P. Price, and M. J. Welsh, Acid-sensing ion channels: advances, questions and therapeutic opportunities, Trends in Neurosciences, vol.29, issue.10, pp.578-586, 2006.
DOI : 10.1016/j.tins.2006.06.014

F. Okajima, Regulation of inflammation by extracellular acidification and proton-sensing GPCRs, Cellular Signalling, vol.25, issue.11, pp.2263-2271, 2013.
DOI : 10.1016/j.cellsig.2013.07.022

S. L. Morales-lázaro, S. A. Simon, and T. Rosenbaum, The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1), The Journal of Physiology, vol.400, issue.13, pp.3109-3130, 2013.
DOI : 10.1113/jphysiol.2013.251751

J. Wemmie, R. J. Taugher, and C. J. Kreple, Acid-sensing ion channels in pain and disease, Nature Reviews Neuroscience, vol.52, issue.7, pp.461-471, 2013.
DOI : 10.1038/nrn3529

M. Ludwig, Proton-sensing G-protein-coupled receptors, Nature, vol.425, issue.6953, pp.93-101, 2003.
DOI : 10.1038/nature01905

J. Wang, TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor, Journal of Biological Chemistry, vol.279, issue.44, pp.45626-45659, 2004.
DOI : 10.1074/jbc.M406966200

E. Ferrannini, The Stunned ?? Cell: A Brief History, Cell Metabolism, vol.11, issue.5, pp.349-52, 2010.
DOI : 10.1016/j.cmet.2010.04.009

P. Rorsman and M. Braun, Regulation of Insulin Secretion in Human Pancreatic Islets, Annual Review of Physiology, vol.75, issue.1, pp.155-79, 2013.
DOI : 10.1146/annurev-physiol-030212-183754

M. A. Atkinson, G. S. Eisenbarth, and A. W. Michels, Type 1 diabetes, The Lancet, vol.383, issue.9911, pp.69-82, 2014.
DOI : 10.1016/S0140-6736(13)60591-7

M. Cnop, Mechanisms of Pancreatic ??-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities, Diabetes, vol.54, issue.Supplement 2, pp.97-107, 2005.
DOI : 10.2337/diabetes.54.suppl_2.S97

J. L. Chiasson, Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state, Cmaj, vol.168, pp.859-866, 2003.

S. P. Efstathiou, A mortality prediction model in diabetic ketoacidosis, Clinical Endocrinology, vol.16, issue.5, pp.595-601, 2002.
DOI : 10.1046/j.1365-2265.2002.01636.x

P. English and G. Williams, Hyperglycaemic crises and lactic acidosis in diabetes mellitus, Postgraduate Medical Journal, vol.80, issue.943, pp.253-61, 2004.
DOI : 10.1136/pgmj.2002.004291

C. Mogi, T. Nakakura, and F. Okajima, Role of extracellular proton-sensing OGR1 in regulation of insulin secretion and pancreatic ^|^beta;-cell functions, Endocrine Journal, vol.61, issue.2, pp.101-111, 2014.
DOI : 10.1507/endocrj.EJ13-0380

S. Huang, W. Yang, Y. Lin, H. Wang, and C. Chen, Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3, Biochemical and Biophysical Research Communications, vol.371, issue.4, pp.729-763, 2008.
DOI : 10.1016/j.bbrc.2008.04.147

M. Tominaga and T. Tominaga, Structure and function of TRPV1, Pfl??gers Archiv - European Journal of Physiology, vol.400, issue.1, pp.143-150, 2005.
DOI : 10.1007/s00424-005-1457-8

Y. Akiba, Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet ?? cells modulates insulin secretion in rats, Biochemical and Biophysical Research Communications, vol.321, issue.1, pp.219-244, 2004.
DOI : 10.1016/j.bbrc.2004.06.149

R. Razavi, TRPV1+ Sensory Neurons Control ?? Cell Stress and Islet Inflammation in Autoimmune Diabetes, Cell, vol.127, issue.6, pp.1123-1135, 2006.
DOI : 10.1016/j.cell.2006.10.038

V. Chandra, RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human ? cells. Cell Rep, pp.2206-2224, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-01103648

R. Scharfmann, Development of a conditionally immortalized human pancreatic ?? cell line, Journal of Clinical Investigation, vol.124, issue.5, pp.2087-98, 2014.
DOI : 10.1172/JCI72674DS1
URL : https://hal.archives-ouvertes.fr/hal-01329344

A. C. Nica, Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome, Genome Research, vol.23, issue.9, pp.1554-1562, 2013.
DOI : 10.1101/gr.150706.112

K. Kim, GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine, The FASEB Journal, vol.19, pp.819-840, 2005.
DOI : 10.1096/fj.04-2988fje

J. Takasaki, A Novel G??q/11-selective Inhibitor, Journal of Biological Chemistry, vol.279, issue.46, pp.47438-47483, 2004.
DOI : 10.1074/jbc.M408846200

H. Tomura, Prostaglandin I2 Production and cAMP Accumulation in Response to Acidic Extracellular pH through OGR1 in Human Aortic Smooth Muscle Cells, Journal of Biological Chemistry, vol.280, issue.41, pp.34458-64, 2005.
DOI : 10.1074/jbc.M505287200

T. Lawrence, The Nuclear Factor NF-??B Pathway in Inflammation, Cold Spring Harbor Perspectives in Biology, vol.1, issue.6, pp.1-10, 2009.
DOI : 10.1101/cshperspect.a001651

C. Kunsch and C. Rosen, NF-kappa B subunit-specific regulation of the interleukin-8 promoter., Molecular and Cellular Biology, vol.13, issue.10, pp.6137-6146, 1993.
DOI : 10.1128/MCB.13.10.6137

M. Baggiolini and I. Clark-lewis, Interleukin-8, a chemotactic and inflammatory cytokine, FEBS Letters, vol.2, issue.1, pp.97-101, 1992.
DOI : 10.1016/0014-5793(92)80909-Z

J. Piccand, Rfx6 Maintains the Functional Identity of Adult Pancreatic ? Cells. Cell Rep, pp.2219-2251, 2014.

D. M. Rosenbaum, S. G. Rasmussen, and B. K. Kobilka, The structure and function of G-protein-coupled receptors, Nature, vol.14, issue.7245, pp.356-363, 2009.
DOI : 10.1038/nature08144

V. Katritch, V. Cherezov, and R. C. Stevens, Structure-Function of the G Protein???Coupled Receptor Superfamily, Annual Review of Pharmacology and Toxicology, vol.53, issue.1, pp.531-56, 2013.
DOI : 10.1146/annurev-pharmtox-032112-135923

D. J. Drucker, Incretin Action in the Pancreas: Potential Promise, Possible Perils, and Pathological Pitfalls, Diabetes, vol.62, issue.10, pp.3316-3323, 2013.
DOI : 10.2337/db13-0822

Z. Zhao, Repurposing cAMP-Modulating Medications to Promote ??-Cell Replication, Molecular Endocrinology, vol.28, issue.10, p.20141120, 2014.
DOI : 10.1210/me.2014-1120

M. Berger, G? i/o-coupled receptor signaling restricts pancreatic ? -cell expansion, Proc. Natl. Acad. Sci. USA, pp.2888-93, 2015.

H. Wang, T. Brun, K. Kataoka, J. Sharma, and C. B. Wollheim, MAFA controls genes implicated in insulin biosynthesis and secretion, Diabetologia, vol.23, issue.Suppl 3, pp.348-358, 2007.
DOI : 10.1007/s00125-006-0490-2

D. Gupta, M. Peshavaria, N. Monga, T. L. Jetton, and J. L. Leahy, Physiologic and Pharmacologic Modulation of Glucose-Dependent Insulinotropic Polypeptide (GIP) Receptor Expression in b-Cells by Peroxisome Proliferator?Activated Receptor (PPAR)-g Signaling, pp.1445-1450, 2010.

J. L. Guénet, The mouse genome, Genome Research, vol.15, issue.12, pp.1729-1740, 2005.
DOI : 10.1101/gr.3728305

J. Hol, L. Wilhelmsen, and G. Haraldsen, The murine IL-8 homologues KC, MIP-2, and LIX are found in endothelial cytoplasmic granules but not in Weibel-Palade bodies, Journal of Leukocyte Biology, vol.87, issue.3, pp.501-508, 2010.
DOI : 10.1189/jlb.0809532

R. Scharfmann, L. Rachdi, and P. Ravassard, Concise Review: In Search of Unlimited Sources of Functional Human Pancreatic Beta Cells, STEM CELLS Translational Medicine, vol.32, issue.suppl 4, pp.61-68, 2013.
DOI : 10.5966/sctm.2012-0120

A. Caicedo, Paracrine and autocrine interactions in the human islet: More than meets the eye, Seminars in Cell & Developmental Biology, vol.24, issue.1, pp.11-21, 2013.
DOI : 10.1016/j.semcdb.2012.09.007

A. G. Patel, Pancreatic interstitial pH in human and feline chronic pancreatitis, Gastroenterology, vol.109, issue.5, pp.1639-1645, 1995.
DOI : 10.1016/0016-5085(95)90654-1

R. Gatenby and R. J. Gillies, Why do cancers have high aerobic glycolysis?, Nature Reviews Cancer, vol.62, issue.11, pp.891-899, 2004.
DOI : 10.1038/nrc1478

Z. Cruz-monserrate, Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment, Scientific Reports, vol.98, issue.2, p.4410, 2014.
DOI : 10.1038/srep04410

J. Son, Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway, Nature, vol.1125, issue.7443, pp.101-106, 2013.
DOI : 10.1038/nature12040

H. Ying, Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism, Cell, vol.149, issue.3, pp.656-670, 2012.
DOI : 10.1016/j.cell.2012.01.058

D. Sebastiano and P. , Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis, Gut, vol.47, issue.3, pp.423-428, 2000.
DOI : 10.1136/gut.47.3.423

F. Hussain, The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours, Cytokine, vol.49, issue.2, pp.134-174, 2010.
DOI : 10.1016/j.cyto.2009.11.010

Y. Chen, Interleukin-8, a promising predictor for prognosis of pancreatic cancer, World Journal of Gastroenterology, vol.18, issue.10, pp.1123-1132, 2012.
DOI : 10.3748/wjg.v18.i10.1123

T. Omatsu, CXCL1/CXCL8 (GRO??/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro, AJP: Endocrinology and Metabolism, vol.306, issue.9, pp.1077-84, 2014.
DOI : 10.1152/ajpendo.00659.2013

H. A. Keenan, Residual Insulin Production and Pancreatic ??-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study, Diabetes, vol.59, issue.11, pp.2846-53, 2010.
DOI : 10.2337/db10-0676

A. K. Davis, Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes, Diabetes Care, vol.38, issue.3, pp.476-81, 2015.
DOI : 10.2337/dc14-1952

L. Dong, Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis, PLoS ONE, vol.21, issue.4, p.61991, 2013.
DOI : 10.1371/journal.pone.0061991.s016

C. R. Justus, L. Dong, and L. Yang, Acidic tumor microenvironment and pH-sensing G protein-coupled receptors, Frontiers in Physiology, vol.4, pp.1-9, 2013.
DOI : 10.3389/fphys.2013.00354

X. Huang, Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65, Nature, vol.8, issue.7579, pp.477-483, 2015.
DOI : 10.1038/nature15699

M. R. Vila, J. Lloreta, and F. Real, Normal human pancreas cultures display functional ductal characteristics, Lab. Invest, vol.71, pp.423-431, 1994.

P. Ravassard, Technical advance A genetically engineered human pancreatic ? cell line exhibiting glucose-inducible insulin secretion, pp.3589-3597, 2011.

N. E. Simpson, L. K. Bennett, K. K. Papas, A. Sambanis, and I. Constantinidis, Effects of pH on Murine Insulinoma ??TC3 Cells, Biochemical and Biophysical Research Communications, vol.273, issue.3, pp.937-941, 2000.
DOI : 10.1006/bbrc.2000.3022

F. Cormier, Frequent Engagement of RelB Activation Is Critical for Cell Survival in Multiple Myeloma, PLoS ONE, vol.26, issue.3, p.59127, 2013.
DOI : 10.1371/journal.pone.0059127.t001

C. A. Kasper, Cell-Cell Propagation of NF-??B Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection, Immunity, vol.33, issue.5, pp.804-820, 2010.
DOI : 10.1016/j.immuni.2010.10.015