A. Fjose, J. Izpisua-belmonte, C. Fromental-ramain, and D. Duboule, Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development, Development, vol.120, issue.1, pp.71-81, 1994.

A. Gershon, J. Rudnick, L. Kalam, and K. Zimmerman, The homeodomaincontaining gene Xdbx inhibits neuronal differentiation in the developing embryo, Development, vol.127, issue.13, pp.2945-54, 2000.

H. Lacin, Y. Zhu, B. Wilson, and J. Skeath, dbx mediates neuronal specification and differentiation through cross-repressive, lineage-specific interactions with eve and hb9, Development, vol.136, issue.19, pp.3257-66, 2009.
DOI : 10.1242/dev.037242

S. Lu, L. Bogarad, M. Murtha, and F. Ruddle, Expression pattern of a murine homeobox gene, Dbx, displays extreme spatial restriction in embryonic forebrain and spinal cord., Proceedings of the National Academy of Sciences, vol.89, issue.17, pp.8053-8060, 1992.
DOI : 10.1073/pnas.89.17.8053

P. Ma, S. Zhao, W. Zeng, Q. Yang, C. Li et al., Xenopus Dbx2 is involved in primary neurogenesis and early neural plate patterning, Biochemical and Biophysical Research Communications, vol.412, issue.1, pp.170-174, 2011.
DOI : 10.1016/j.bbrc.2011.07.068

H. Seo, F. Nilsen, and A. Fjose, Three structurally and functionally conserved Hlx genes in zebrafish, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol.1489, issue.2-3, pp.2-3323, 1999.
DOI : 10.1016/S0167-4781(99)00187-6

H. Shoji, T. Ito, Y. Wakamatsu, N. Hayasaka, K. Ohsaki et al., Regionalized expression of the Dbx family homeo??? genes in the embryonic CNS of the mouse, Mechanisms of Development, vol.56, issue.1-2, pp.25-39, 1996.
DOI : 10.1016/0925-4773(96)00509-6

S. Gribble, O. Nikolaus, and R. Dorsky, Regulation and function ofDbx genes in the zebrafish spinal cord, Developmental Dynamics, vol.303, issue.12, pp.3472-83, 2007.
DOI : 10.1002/dvdy.21367

J. Hjorth, R. Connor, and B. Key, Role of hlx1 in zebrafish brain morphogenesis, Int J Dev Biol, vol.46, issue.4, pp.583-96, 2002.

A. Pierani, L. Moran-rivard, M. Sunshine, D. Littman, M. Goulding et al., Control of Interneuron Fate in the Developing Spinal Cord by the Progenitor Homeodomain Protein Dbx1, Neuron, vol.29, issue.2, pp.367-84, 2001.
DOI : 10.1016/S0896-6273(01)00212-4

G. Lanuza, S. Gosgnach, A. Pierani, T. Jessell, and M. Goulding, Genetic Identification of Spinal Interneurons that Coordinate Left-Right Locomotor Activity Necessary for Walking Movements, Neuron, vol.42, issue.3, pp.375-86, 2004.
DOI : 10.1016/S0896-6273(04)00249-1

A. Talpalar, J. Bouvier, L. Borgius, G. Fortin, A. Pierani et al., Dual-mode operation of neuronal networks involved in left???right alternation, Nature, vol.34, issue.7460, pp.85-93, 2013.
DOI : 10.1038/nature12286

URL : https://hal.archives-ouvertes.fr/hal-00850721

J. Bouvier, M. Thoby-brisson, N. Renier, V. Dubreuil, J. Ericson et al., Hindbrain interneurons and axon guidance signaling critical for breathing, Nature Neuroscience, vol.18, issue.9, pp.1066-74, 2010.
DOI : 10.1111/j.1460-9568.2008.06345.x

URL : https://hal.archives-ouvertes.fr/hal-00517787

P. Gray, J. Hayes, G. Ling, I. Llona, S. Tupal et al., Developmental Origin of PreBotzinger Complex Respiratory Neurons, Journal of Neuroscience, vol.30, issue.44, pp.14883-95, 2010.
DOI : 10.1523/JNEUROSCI.4031-10.2010

K. Sokolowski, S. Esumi, T. Hirata, Y. Kamal, T. Tran et al., Specification of Select Hypothalamic Circuits and Innate Behaviors by the Embryonic Patterning Gene Dbx1, Neuron, vol.86, issue.2, pp.403-419, 2015.
DOI : 10.1016/j.neuron.2015.03.022

J. Muhr, E. Andersson, M. Persson, T. Jessell, and J. Ericson, Groucho-Mediated Transcriptional Repression Establishes Progenitor Cell Pattern and Neuronal Fate in the Ventral Neural Tube, Cell, vol.104, issue.6, pp.861-73, 2001.
DOI : 10.1016/S0092-8674(01)00283-5

S. Lee and S. Pfaff, Transcriptional networks regulating neuronal identity in the developing spinal cord, Nature Neuroscience, vol.4, issue.Supp, pp.1183-91, 2001.
DOI : 10.1038/nn750

L. Holm and C. Sander, Parser for protein folding units, Proteins: Structure, Function, and Genetics, vol.347, issue.3, pp.256-68, 1994.
DOI : 10.1002/prot.340190309

C. Chothia, J. Gough, C. Vogel, and S. Teichmann, Evolution of the Protein Repertoire, Science, vol.300, issue.5626, pp.1701-1704, 2003.
DOI : 10.1126/science.1085371

D. Babushok, E. Ostertag, H. Kazazian, and . Jr, Current topics in genome evolution: Molecular mechanisms of new gene formation, Cellular and Molecular Life Sciences, vol.64, issue.5, pp.542-54, 2007.
DOI : 10.1007/s00018-006-6453-4

S. Meier, P. Jensen, C. David, J. Chapman, T. Holstein et al., Continuous Molecular Evolution of Protein-Domain Structures by Single Amino Acid Changes, Current Biology, vol.17, issue.2, pp.173-181, 2007.
DOI : 10.1016/j.cub.2006.10.063

J. Cheng, M. Sweredoski, and P. Baldi, DOMpro: Protein Domain Prediction Using Profiles, Secondary Structure, Relative Solvent Accessibility, and Recursive Neural Networks, Data Mining and Knowledge Discovery, vol.13, issue.1, pp.1-10, 2006.
DOI : 10.1007/s10618-005-0023-5

R. Edgar, MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic Acids Research, vol.32, issue.5, pp.1792-1799, 2004.
DOI : 10.1093/nar/gkh340

A. Dereeper, V. Guignon, G. Blanc, S. Audic, S. Buffet et al., Phylogeny.fr: robust phylogenetic analysis for the non-specialist, Nucleic Acids Research, vol.36, issue.Web Server, pp.465-474, 2008.
DOI : 10.1093/nar/gkn180

URL : https://hal.archives-ouvertes.fr/lirmm-00324099

S. Guindon, J. Dufayard, V. Lefort, M. Anisimova, W. Hordijk et al., New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0, Systematic Biology, vol.59, issue.3, pp.307-328, 2010.
DOI : 10.1093/sysbio/syq010

URL : https://hal.archives-ouvertes.fr/lirmm-00511784

M. Anisimova and O. Gascuel, Approximate Likelihood-Ratio Test for Branches: A Fast, Accurate, and Powerful Alternative, Systematic Biology, vol.55, issue.4, pp.539-52, 2006.
DOI : 10.1080/10635150600755453

URL : https://hal.archives-ouvertes.fr/lirmm-00136658

R. Adamczak, A. Porollo, and J. Meller, Combining prediction of secondary structure and solvent accessibility in proteins, Proteins: Structure, Function, and Bioinformatics, vol.10, issue.3, pp.467-75, 2005.
DOI : 10.1002/prot.20441

V. Hamburger and H. Hamilton, A series of normal stages in the development of the chick embryo, Journal of Morphology, vol.108, issue.1, pp.49-92, 1951.
DOI : 10.1002/jmor.1050880104

A. Pierani, S. Brenner-morton, C. Chiang, and T. Jessell, A Sonic Hedgehog???Independent, Retinoid-Activated Pathway of Neurogenesis in the Ventral Spinal Cord, Cell, vol.97, issue.7, pp.903-918, 1999.
DOI : 10.1016/S0092-8674(00)80802-8

P. Sigler, Acid blobs and negative noodles, Nature, vol.333, issue.6170, pp.210-212, 1988.
DOI : 10.1038/333210a0

F. Bushman and M. Ptashne, Turning ? Cro into a transcriptional activator, Cell, vol.54, issue.2, pp.191-198, 1988.
DOI : 10.1016/0092-8674(88)90551-X

M. Ptashne, The Chemistry of Regulation of Genes and Other Things, Journal of Biological Chemistry, vol.289, issue.9, pp.5417-5452, 2014.
DOI : 10.1074/jbc.X114.547323

S. Yamamoto, A. Eletsky, T. Szyperski, J. Hay, and W. Ruyechan, Analysis of the Varicella-Zoster Virus IE62 N-Terminal Acidic Transactivating Domain and Its Interaction with the Human Mediator Complex, Journal of Virology, vol.83, issue.12, pp.6300-6305, 2009.
DOI : 10.1128/JVI.00054-09

S. Kuraku, A. Meyer, and S. Kuratani, Timing of Genome Duplications Relative to the Origin of the Vertebrates: Did Cyclostomes Diverge before or after?, Molecular Biology and Evolution, vol.26, issue.1, pp.47-59, 2009.
DOI : 10.1093/molbev/msn222

J. Smith, S. Kuraku, C. Holt, T. Sauka-spengler, N. Jiang et al., Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution, Nature Genetics, vol.38, issue.4, pp.415-436, 2013.
DOI : 10.1093/nar/gkh053

J. Briscoe, A. Pierani, T. Jessell, and J. Ericson, A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube, Cell, vol.101, issue.4, pp.435-480, 2000.
DOI : 10.1016/S0092-8674(00)80853-3

L. Moran-rivard, T. Kagawa, H. Saueressig, M. Gross, J. Burrill et al., Evx1 Is a Postmitotic Determinant of V0 Interneuron Identity in the Spinal Cord, Neuron, vol.29, issue.2, pp.385-99, 2001.
DOI : 10.1016/S0896-6273(01)00213-6

A. Thelie, S. Desiderio, J. Hanotel, I. Quigley, B. Van-driessche et al., Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus, Development, vol.142, issue.19, pp.3416-3444, 2015.
DOI : 10.1242/dev.121871

URL : https://hal.archives-ouvertes.fr/hal-01266963

A. Pani, E. Mullarkey, J. Aronowicz, S. Assimacopoulos, E. Grove et al., Ancient deuterostome origins of vertebrate brain signalling centres, Nature, vol.17, issue.7389, pp.289-94, 2012.
DOI : 10.1038/nature10838

Y. Yao, P. Minor, Y. Zhao, Y. Jeong, A. Pani et al., Cis-regulatory architecture of a brain signaling center predates the origin of chordates, Nature Genetics, vol.124, issue.5, pp.575-80, 2016.
DOI : 10.1371/journal.pbio.0040291

R. Galant and S. Carroll, Evolution of a transcriptional repression domain in an insect Hox protein, Nature, vol.415, issue.6874, pp.910-913, 2002.
DOI : 10.1038/nature717

M. Ronshaugen, N. Mcginnis, and W. Mcginnis, Hox protein mutation and macroevolution of the insect body plan, Nature, vol.415, issue.6874, pp.914-921, 2002.
DOI : 10.1038/nature716

G. Vachon, B. Cohen, C. Pfeifle, M. Mcguffin, J. Botas et al., Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less, Cell, vol.71, issue.3, pp.437-50, 1992.
DOI : 10.1016/0092-8674(92)90513-C