Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis

Filipe De Vadder 1, 2 Flora Plessier 2, 1 Amandine Gautier-Stein 2, 1 Gilles Mithieux 2, 1, *
* Auteur correspondant
1 Université de Lyon
2 Nutrition et cerveau (U1213, U855)
Abstract : Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (1) VIP signaling through VPAC1 receptor activates the intestinal glucose-6-phosphatase gene in vivo, (2) the activation of IGN by propionate is counteracted by VPAC1 antagonism, and (3) VIP-positive intrinsic neurons in the submucosal plexus are increased under the action of propionate. These data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction through a VPAC1 receptor-dependent mechanism in enterocytes.
Keywords : glucose-6- phosphatase KEY MESSAGES Intestinal gluconeogenesis vasoactive intestinal peptide gut-brain axis
Type de document :
Article dans une revue
Neurogastroenterology and Motility, Wiley, 2015, 27 (3), pp.443-448. 〈10.1016/j.molmet.2014.12.009〉
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Contributeur : Marie-Ange Di Carlo <>
Soumis le : mardi 2 août 2016 - 11:24:59
Dernière modification le : mardi 27 mars 2018 - 14:02:02
Document(s) archivé(s) le : jeudi 3 novembre 2016 - 18:10:06

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Filipe De Vadder, Flora Plessier, Amandine Gautier-Stein, Gilles Mithieux. Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis. Neurogastroenterology and Motility, Wiley, 2015, 27 (3), pp.443-448. 〈10.1016/j.molmet.2014.12.009〉. 〈inserm-01350922〉

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