The Hidden side of SERPINB1/Leukocyte Elastase Inhibitor - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Seminars in Cell and Developmental Biology Year : 2017

The Hidden side of SERPINB1/Leukocyte Elastase Inhibitor


SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS . It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases. LEI/SERPINB1 intrinsically possesses two enzymatic activities: an antiprotease activity dependent on its reactive site loop, which is analogous to the other proteins of the family and an endonuclease activity which is unveiled by the cleavage of the reactive site loop. The conformational change induced by this cleavage also unveils a bipartite nuclear localization signal allowing the protein to translocate to the nucleus. Recent data indicate that it has also a role in cell migration suggesting that it could be involved in diverse processes like wound healing and malignant metastases.
Fichier principal
Vignette du fichier
SerpinB1_HAL.pdf (284.19 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-01349216 , version 1 (27-07-2016)



Alicia Torriglia, Elisabeth Martin, Imene Jaadane. The Hidden side of SERPINB1/Leukocyte Elastase Inhibitor. Seminars in Cell and Developmental Biology, 2017, 62, pp.178-186. ⟨10.1016/j.semcdb.2016.07.010⟩. ⟨inserm-01349216⟩
218 View
329 Download



Gmail Facebook Twitter LinkedIn More